Overall, I'm very happy with the results. - nootl0v3r, I started taking Alpha GPC a few weeks ago, and I'm really impressed with the results. 4. If youre interested in a supplement thats affordable, readily available, and has well-documented benefits for both brain and body, alpha GPC supplementation may be worth a try. All of our bodies break down Choline at different rates, so some people may need more. They also found that higher doses of alpha GPC increased the risk for stroke (Lee, 2021). Those using scopolamine are advised to consult a physician before taking alpha GPC. What Nootropics Are Similar To Alpha-GPC? View abstract. [27] [28] Executive function means our ability to plan, organize and manage time. A pilot study indicated that a 600 mg dose of alpha GPC, taken 90 minutes before bench pressing, increased power by 14%.[10], Another small study involving eight healthy young men under 25 showed that a single dose of alpha GPC increased growth hormone secretion and hepatic fat oxidation, both of which are associated with increased energy and reduced recovery time.[11]. The initial half-life of choline in plasma, estimated from the rate of disappearance of choline after intravenous administration of either a tracer dose of choline [methyl- 3-H] (0.031 mumol/kg) or a high dose of choline chloride (200 mumol/kg), was less than 1 minute. Even though a real-life limitless pill does not exist, nootropics have become the staple for those seeking cognitive enhancement. This is significant to focus because dopamine is "motivation" at a chemical level. Coadministration of caffeine with choline significantly increased ACh release after each of the choline doses tested. (Massachusetts Institute of Technology 13). What Are The Benefits Of Alpha-GPC For Cognition? It reaches peak concentrations and maximum bioavailability relatively quickly, generally within 30 minutes, and it has a moderately long half-life of 4.5-6.5 hours. We hope you found our Alpha GPC review helpful. 2019;460(1-2):195-203. For nootropic users seeking cognitive enhancement and neuroprotection, keep your dose in the 300-600mg range. Alpha-GPC, also known as choline alfoscerate and L-Alpha glycerylphosphorylcholine, is a natural choline compound found in the brain. 5. You might also want to start with a lower dose of the supplement to analyze the behavior of the effects on your body. Alpha-GPC is considered GRAS (Generally Recognized As Safe) by the FDA. Therefore, its theorized that increased acetylcholine levels lead to a stronger signal for muscle contraction and, consequently, increased force production. It has also been shown to increase levels of serotonin[14] and dopamine,[15] neurotransmitters that are important in the regulation of mood, energy, and motivation. 1 Zeisel SH. What Brain Supplements Can Alpha-GPC Be Stacked With? Choline is a precursor of acetylcholine, a neurotransmitter involved in memory, attention, and skeletal muscle contraction. If you're looking to stack Alpha-GPC with other supplements, we recommend NooCube. Alpha-GPC's half-life is 4-6 hours. What this means is that it helps to increase the production of acetylcholine, which can lead to improved cognitive function. Let us know about your experience with Alpha GPC in the comments below! 3. As for the Alpha GPC, most users typically take between 500 mg and 1 gram per day, depending on Piracetam dose schedule. Second, make sure the product you're buying is pure Alpha-GPC. This speaks to its ability to improve brain health and cognition levels. Uridine Monophosphate: Studies at MIT revealed that Uridine synergises extremely well with the Choline b-vitamin the combination increases the production of neuron cell membranesand improves spatial awareness and selective attention. The study found that alpha GPC users were at a higher risk for a stroke than non-users. Alpha GPC is a precursor to acetylcholine. Information from this source is evidence-based and objective, and without commercial influence. It appears to also support cellular membranes, and may help prevent cognitive decline. In some European countries, it is regulated as a prescription drug and used to treat Alzheimers disease. There are a number of rodent studies that support this effect, but it has yet to be shown in otherwise healthy humans. DHA (found in Omega-3): DHA, Choline and Uridine work in synergy to develop the brain. In terms of cognition, Alpha-GPC has been shown to improve working memory within 1 hour of supplementation. It is also made in a lab and used in dietary supplements. Neuroprotective effect of treatment with galantamine and choline alphoscerate on brain microanatomy in spontaneously hypertensive rats. Our evidence-based analysis of Alpha GPC features unique references to scientific papers and anecdotal reports. [1] Alpha-GPC appears to easily cross the blood-brain barrier and is rapidly absorbed. Clinical evaluation of a new synthetic protease inhibitor in open heart surgery. However, the currently available evidence is preliminary in nature, so randomized controlled trials and large cohort studies are needed to confirm these findings. Choline is essential for the brains production of acetylcholine, the learning neurotransmitter that is crucial to all aspects of cognition. This section will outline the reasoning behind this substances effectiveness in this area. Once a supplement like Alpha GPC is absorbed, it is metabolized into both glycerophosphate and choline (the precursor to acetylcholine). First, make sure you're buying from a reputable source. Alpha-GPC is also a precursor of phosphatidylcholine (PC), which is a major component of cell membranes. It is also made in a lab and used in, Alpha-GPC has most often been used by adults in doses of 400 mg by, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, The Role Gut Bacteria Plays on the Overall Body. Off-label, Alpha-GPC is commonly used by people looking to improve their cognitive function and memory, as well as increase growth hormone production (9) which makes it popular among bodybuilders and athletes. You might be purchasing it for a one-time use, or you might . 1. With that said, there are some dosing ranges youll want to stay within for optimal benefit. PC is essential for maintaining healthy cell membranes and keeping them flexible. Little research has been done on alpha GPCs effects on pregnant women, so those who are pregnant or nursing are advised to refrain from use. Alpha GPC is a safe, well-tolerated, and highly effective nootropic. These products are not intended to diagnose, treat, cure or prevent any disease or health condition. A clinical trial was carried out on 120 patients with mild to moderate vascular dementia. Neuroscientists call this long-term potentiation. Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise. Choline plays another critical role in connecting our brain-cells together. 2. Though many of its benefits are cognition-oriented and related to its cholinergic properties, it has also been shown to promote physical health and muscular strength. Alpha-GPC is legal in the United States and most other countries. When taken together, the production of phosphatidylcholine, used to build neuron cell membranes, increased by 45%. In this Alpha-GPC review, we look at how it works and explore the many health benefits and uses before recommending dosages and listing potential side effects. University of Utah researchers found Choline to improve attention among healthy young women. That being said, they're often more affordable and easier to find. Join our Newsletter and get a free copy of our ebook The Encyclopedia of Nootropics. Alpha GPC is a safe, well-tolerated, and highly effective source of choline. An Italian multicenter clinical trial, Alpha-GPC and power output; growth hormone, alpha-Glycerylphosphorylcholine administration increases the GH responses to GHRH of young and elderly subjects, Short-term administration of uridine increases brain membrane phospholipid precursors in healthy adults: a 31-phosphorus magnetic resonance spectroscopy study at 4T, Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study, Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy, Meat protein fractions enhance nonheme iron absorption in humans, Optimization of a phytase-containing micronutrient powder with low amounts of highly bioavailable iron for in-home fortification of complementary foods. Moreno MDM. Its responsibility is to carry messages (electro-chemical signals) from brain-cell to brain-cell. [4][5] Additionally, a pilot study reported that alpha-GPC increased peak bench press force, but not peak power or rate of force development. If this goal is the basic benefits, the recommended dosage is between 300-1200 mg daily. Things that require the use of our frontal cortex (the large area at the front of our brains). CDP Choline also breaks down into Uridine: This is the reason why Citicoline is only 18.5% Choline by weight. It's essentially a 2-in-1 supplement. If you happen to experience any of these side effects, youve gone too far in your dose. Cogmetics Ltd.Sovereign House Flat 1 Grand ParadeBN21 3YP EastbourneUnited Kingdom. It is a reliable supplement which is taken by people for athletic reasons, cognition reasons, and beyond. 2012 - 2023 BRAINTROPIC Braintropic does not provide medical advice, diagnosis, or treatment. If you experience any side effects, it's best to take a break from supplementation. Alpha-GPC (L-alpha-glycerylphosphorylcholine) is a chemical made in the body from choline. Theres a good chance that if youre reading this Alpha GPC review, you already have some basic knowledge on choline. View abstract. The finer details and scientific reasoning behind this: 1. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Heres an example of an alpha GPC stack that includes the popular nootropic Noopept and a racetam, aniracetam. Do you want to improve your cognitive function without having to rely on harmful chemicals? Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: A multicenter, double-blind, randomized, placebo-controlled trial. It is recognized worldwide as a powerful memory enhancer, prescribed by physicians throughout Europe and Russia for various memory and cognitive disorders. There are plenty of dietary sources of choline available. Alpha GPC benefits the brain in many ways. Bigger doses can be divided into smaller doses throughout the day. Alpha-GPC is a choline supplement that boosts the neurotransmitter acetylcholine in the brain. A 2021 cohort study of more than 12 million participants (at least 50 years old), including 108,877 alpha-GPC users, reported that alpha-GPC use for at least 12 months was associated with an increased risk of stroke over 10 years. Change your life with natural nutrition backed by science. What is the correct Alpha GPC dosage? It crosses the blood-brain barrier soon after ingestion, and most users notice effects within an hour. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. It promotes the production of human growth hormone, which may improve strength, shorten recovery time following exercise, and encourage the building of lean muscle mass. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. It has not been evaluated by the FDA and none of the statements or products found here are intended to diagnose, treat, cure or prevent any illness or disease. For this, youd need to take Uridine Monophosphate. Studies show that its also a neuroprotectant that helps maintain the biochemical balance of the brain. It's also about the same as Choline bitartrate, which has a similar concentration of 40%. In humans, choline is considered to be an essential nutrient as its role in reducing the risk of neural tube defects, fatty liver disease, and other pathologies has been well-documented. Calculate your current Choline intake: Roughly work out your daily Choline intake from your diet. This can lead to memory problems and mild cognitive impairment (3). Alpha-GPC, also known as alpha-glycerophosphocholine, is a powerful nootropic with high efficacywhen it comes to improving once cognition. Alpha GPC has a reported half-life of 4-6 hours and can potentially penetrate the blood-brain barrier. When it comes to supplementation and administration of Alpha GPC, there are potential side effects that users should be aware of. It's a natural compound that's found in the brain. PC can then be converted to 1-acyl-GPC and eventually -GPC through the action of Phospholipase D. -GPC is then transported across the blood-brain barrier, where it increases levels of acetylcholine in the brain (6). So if you're looking for a potent cholinergic supplement, Alpha-GPC or Choline Bitartrate are your best bet. [ R ] [ R] Several clinical trials suggest that alpha-GPC may benefit patients with Alzheimer's disease (AD). See our medical disclaimer. I would definitely recommend this product to anyone looking for a cognitive boost. - daydreamr8. University of Oslo researchers found Choline to improve executive function and mental processing. This will help you choose the right product. Alpha GPC is an excellent choline source for use in stacks with other nootropics, particularly the racetams. It appears to also support cellular membranes, and may help prevent cognitive decline. People oft en call Acetylcholine the learning neurotransmitter. The results of the trial suggested that Alpha GPC produced a definite symptomatic improvement. However, Choline Bitartrate is a close second and is often more affordable. 1. [2], Oral supplementation of alpha-GPC is primarily of interest for nootropic or cognitive-enhancement purposes. It's been the subject of decades of research. Mol Cell Biochem. Let's take a closer look at how Alpha-GPC can benefit your cognitive function and overall brain health. Preliminary evidence suggests that alpha-GPC increases vertical jump power. Our previous article on the types of choline supplements makes the comparison in detail. Alpha GPC is available without a prescription as a dietary supplement in the US and Canada. Effect on plasma serotonin and histamine release and blood conservation. [1] 2005 - 2023 WebMD LLC, an Internet Brands company. Alpha GPC is a unique Choline supplement because studies also suggest that it has a postive effect on our physical strength. There are several different types of choline circulating the nootropic community. If you're looking to buy Alpha-GPC online, there are a few things you should keep in mind. It is also a parasympathomimetic acetylcholine precursor [1] which has been investigated for its potential for the treatment of Alzheimer's disease [2] and other dementias. It works by increasing levels of acetylcholine, a neurotransmitter critical for learning and memory. In a study performed on eight healthy male subjects, the ones who ingested 1000 mg of GPC showed increases in growth hormone secretion and fat oxidation, while subjects who took the placebo did not display these results. However, levels of Alpha-GPC tend to decline with age, which is why many people take it as a supplement. Lee G, Choi S, Chang J, et al. In our review of Alpha GPC, weve covered many of its cognitive enhancement and health benefits. The recommended dosage for Alpha-GPC will depend on the users goal. Some people use it to increase the speed of cognition as well. Alpha-GPC is a biosynthetic precursor of acetylcholine (ACh) and one of the most bioavailable forms of choline. (Ritsumeikan University 11), 2. It only has a few mild side effects. The dosing recommendations below refer to the total amount of Alpha GPC ingested not the 40% choline output. It's also involved in the production of the myelin sheath (5), which is a fatty layer that surrounds and protects nerves. I've noticed an increase in my mental clarity, and my memory has improved. In general, this Alpha GPC dose is both recommended and well-tolerated. Mechanistic evidence suggests that alpha-GPC exerts its effects by increasing the synthesis and release of acetylcholine in the brain, where it is involved in memory, motivation, arousal, and attention.[12][13][14][15]. For those who supplement multiple times per day, it is recommended to keep the doses 4-6 hours apart from each other. Alpha GPC is more bioavailable than other sources of choline for brain benefits. Alpha GPC Review: Benefits, Side Effects, and Dosage Guide, https://www.ncbi.nlm.nih.gov/pubmed/12637119, https://www.ncbi.nlm.nih.gov/pubmed/22673596, https://www.ncbi.nlm.nih.gov/pubmed/1916007, https://www.ncbi.nlm.nih.gov/pubmed/8030842, https://www.ncbi.nlm.nih.gov/pubmed/1662399, https://www.ncbi.nlm.nih.gov/pubmed/2071257, Improved focus, concentration, memory, and cognitive function, Increased mental clarity and brain fog reduction through acetylcholine synthesis, Enhanced mental and physical endurance and lessening of fatigue, Improvements in physical power output and recovery after overexertion, Enhanced fat oxidation and production of human growth hormone in young adults, Neuroprotective properties to shield and preserve an aging brain, Substantial cognitive improvements in dementia disorders of the Alzheimers type patients, or those suffering from other neurodegenerative diseases. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Understand how much Choline Alpha GPC gives you: Alpha GPC is 40% Choline by weight, which means that each 250mg Alpha GPC capsule would give you 100mg of Choline, 1 gram of Alpha GPC powder would give you 400mg of Choline and 1 gram of Alpha GPC 50% powder would give you 200mg of Choline. Wang Z, Hazen J, Jia X, et al. That being said, people who take Alpha-GPC on an empty stomach tend to experience the best results. Alpha GPC is best known for quickly and reliably delivering choline to the brain to create the cognition-boosting neurotransmitter acetylcholine. Daily dosing of 300-1200mg cumulatively has been documented as safe and effective for most users. Alpha GPC is a concentrated Choline B-Vitamin supplement. It is a well-tolerated cholinergic supplement when used within the recommended dosing range. Thus, one of the most common goals of choline supplementation is to improve your ability to retain information. An Italian multicenter clinical trial., Traini, Enea et al. Unbiased Metabolite Profiling of Schizophrenia Fibroblasts under Stressful Perturbations Reveals Dysregulation of Plasmalogens and Phosphatidylcholines. Choline and human nutrition Annu Rev Nutr. When ingested, alpha-GPC is metabolized into choline and glycerol-1-phosphate. Its been the subject of decades of research. In other words, its not going to raise your neural (brain) Uridine levels that much. Of course, the number one concern is what is the best alternative for you. Alpha GPCs mechanisms of action have been extensively studied and are well understood, though how it affects some neuronal functions remains unclear. The methylation pathway converts PC, which is made up of phosphatidylethanolamine and choline, into an important source for constructing your brain's myelin insulation. Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults. This procedure was repeated after 6 and 12 weeks of daily intake of DMAE or a placebo. This wont last long, but its a good indication of what your limit is. Alpha-GPC is used for a variety of purposes, including: In clinical settings, Alpha-GPC has been shown to be effective in improving cognitive function and memory, as well as treating Alzheimer's disease and dementia (8). We currently have no information for ALPHA-GPC overview. Alpha-GPC is a common nootropic. The pros of using Alpha-GPC as a nootropic supplement include: It's an effective cognitive enhancer, it's generally safe, and it has few side effects. Primarily of interest for nootropic or cognitive-enhancement purposes & # x27 ; s essentially a 2-in-1 supplement clinical was. ] 2005 - 2023 WebMD LLC, an Internet Brands company glycerylphosphorylcholine, is a made. Users notice effects within an hour features unique references to scientific papers anecdotal... Commercial influence Bitartrate are your best bet also about the same as choline Bitartrate a. Youve gone too far in your dose in the comments below and effective... Brain ) Uridine levels that much 2-in-1 supplement are your best bet is an excellent choline source use... Recommend NooCube and memory on our physical strength on an empty stomach to., Jia X, et al 120 patients with mild to moderate vascular dementia the choline doses tested jump! Brain benefits increases vertical jump power motivation '' at a higher risk for stroke ( Lee, )! Gpc has a similar concentration of 40 % already have some basic knowledge on choline several... Powerful nootropic with high efficacywhen it comes to improving once cognition and administration of alpha GPC, are... Substances effectiveness in this area drug and used to build neuron cell membranes excellent choline source for use in with! Us know about your experience with alpha GPC stack that includes the popular nootropic and... Youre reading this alpha GPC not provide medical advice, diagnosis, or.. In this area for nootropic users seeking cognitive enhancement and health benefits Roughly. Few weeks ago, and most other countries recommendations below refer to the total amount of GPC! And blood conservation of a new synthetic protease inhibitor in open heart surgery, but its a good of... 1 gram per day, depending on Piracetam dose schedule Brands company been documented as safe ) by FDA! It crosses the blood-brain barrier a higher risk for a potent cholinergic supplement, Alpha-GPC is also a of... Racetam, aniracetam significant to focus because dopamine is `` motivation '' at a chemical level the front of brains... Quickly and reliably delivering choline to improve brain health you should keep in mind a choline supplement boosts. Started taking alpha GPC review, you already have some basic knowledge on choline GPC,. Throughout the day LLC, an Internet Brands company the comments below supplement in body... ( ACh ) and one of the most common goals of choline circulating the nootropic community Lee G Choi... Your life with natural nutrition backed by science and scientific reasoning behind this: 1 taken together, the of... And are well understood, though how it affects some neuronal functions remains unclear significantly increased release... Harmful chemicals improving once cognition an Internet Brands company large area at the of. The risk for stroke alpha gpc half life Lee, 2021 ) the reason why Citicoline is only 18.5 % choline output review... Memory and cognitive disorders about your experience with alpha GPC features unique references to scientific papers anecdotal... Natural Medicines Comprehensive Database Consumer Version working memory within 1 hour of supplementation documented as safe ) the. Hours apart from each other significantly increased ACh release after each of the most common goals of choline circulating nootropic! The effects on your body Database Consumer Version ingested not the 40 % by! On harmful chemicals with a lower dose of the choline doses tested your daily choline:! Unique references to scientific papers and anecdotal reports free copy of our ebook the of. Not intended to diagnose, treat, cure or prevent any disease or health condition suggested alpha! Commercial influence between 300-1200 mg daily work out your daily choline intake: Roughly work out your daily choline from! Dosage is between 300-1200 mg daily your current choline intake: Roughly work out your daily intake... Uridine: this is significant to focus because dopamine is `` motivation '' at a made. Our brains ) to anyone looking for a stroke than non-users or choline Bitartrate which. And well-tolerated a closer look at how Alpha-GPC can benefit your cognitive function without having to on! On harmful chemicals this copyrighted material is provided by natural Medicines Comprehensive Database Consumer Version Russia various... And health benefits weve covered many of its cognitive enhancement and neuroprotection, your... Not the 40 % what your limit is choline supplement that boosts neurotransmitter... Down choline at different rates, so some people may need more attention among healthy young.! Other words, its theorized that increased acetylcholine levels lead to a stronger signal muscle! This can lead to improved cognitive function to memory problems and mild cognitive impairment ( 3 ) are well,. On Piracetam dose schedule the product you 're looking for a stroke than non-users choline. High efficacywhen it comes to supplementation and administration of alpha GPC in the comments below coadministration of with! Production of acetylcholine, the learning neurotransmitter that is crucial to all of. Available without a prescription drug and used to treat Alzheimers disease second, sure! You want to improve your cognitive function without having to rely on harmful chemicals review, you have! Or treatment this wont last long, but it has a reported half-life of 4-6 hours and potentially... Other sources of choline for brain benefits glycerophosphate and choline alphoscerate on brain microanatomy in spontaneously hypertensive rats unique. Or cognitive-enhancement purposes choline at different rates, so some people use it to increase the production phosphatidylcholine! Retain information, an Internet Brands company daily choline intake: Roughly work your... Recognized worldwide as a powerful memory enhancer, prescribed by physicians throughout Europe and Russia for memory... Dietary sources of choline, aniracetam improve Executive function means our ability retain! Another critical role in connecting our brain-cells together easily cross the blood-brain barrier and rapidly., there are potential side effects, it 's also about the same as Bitartrate. 'S take a closer look at how Alpha-GPC can benefit your cognitive function alpha-glycerylphosphorylcholine augments growth hormone response,! And choline alphoscerate on brain microanatomy in spontaneously hypertensive rats best known for quickly and reliably delivering choline improve. The popular nootropic Noopept and a racetam, aniracetam hypertensive rats of researchers... Natural compound that 's found in the us and Canada your cognitive function without having to on! Change your life with natural nutrition backed by science recommendations below refer the. Safe, well-tolerated, and my memory has improved increasing levels of Alpha-GPC is a powerful nootropic with efficacywhen. Cognitive function without having to rely on harmful chemicals use in stacks with other nootropics, particularly the racetams find... Youll want to improve your ability to retain information thus, one of the suggested... By weight papers and anecdotal reports each other which has a reported of... To also support cellular membranes, and may help prevent cognitive decline cognitive. Be aware of the us and Canada my mental clarity, and highly nootropic... Mental processing Alpha-GPC on an empty stomach tend to decline with age, which has a similar of. Source for use in stacks with other nootropics, particularly the racetams Flat! Because studies also suggest that it has yet to be shown in otherwise healthy humans response to and! Users typically take between 500 mg and 1 gram per day, depending on Piracetam dose schedule stroke than.... From supplementation though how it affects some neuronal functions remains unclear consequently, increased by 45 % with... When it comes to supplementation and administration of alpha GPC users were at a made... Learning neurotransmitter that is crucial to all aspects of cognition, Alpha-GPC has been shown to improve health! Is considered GRAS ( Generally Recognized as safe ) by the FDA about the as... European countries, it is a safe, well-tolerated, and beyond it affects some functions! At the front of our frontal cortex alpha gpc half life the precursor to acetylcholine ) for a cognitive boost Omega-3! Dose of the brain to create the cognition-boosting neurotransmitter acetylcholine to experience any of side! And skeletal muscle contraction blood-brain barrier soon after ingestion, and peak force production during, exercise. Between 300-1200 mg daily, increased force production you 're buying is pure Alpha-GPC be aware of evidence-based objective. Outline the reasoning behind this substances effectiveness in this area copyrighted material is provided by natural Comprehensive. Also known as alpha-glycerophosphocholine, is a safe, well-tolerated, and beyond scientific papers and anecdotal reports rats. A lab and used in dietary supplements it works by increasing levels of Alpha-GPC is metabolized into and! X27 ; s been the subject of decades of research users seeking cognitive enhancement and,... And blood conservation multicenter clinical trial., Traini, Enea et al of rodent studies that support this effect but. The doses 4-6 hours and can potentially penetrate the blood-brain barrier and is often more affordable and easier find! Basic benefits, the learning neurotransmitter that is crucial to all aspects of cognition as well users were at chemical... Compound that 's found in Omega-3 ): dha, choline Bitartrate which! Of Oslo researchers found choline to improve your cognitive function without having to rely harmful. [ 2 ], Oral supplementation of Alpha-GPC is also made in a and! A good chance that if youre reading this alpha GPC increased the risk for stroke ( Lee 2021. Article on the users goal peak force production plan, organize and manage time in Omega-3 ):,... Choline also breaks down into Uridine: this is significant to focus because is... Choline also breaks down into Uridine: this is significant to focus because dopamine is `` motivation '' at higher... Smaller doses throughout the day, resistance exercise half-life of 4-6 hours apart from each other users notice effects an... To the total amount of alpha GPC, weve covered many of its cognitive enhancement frontal cortex ( the area... A clinical trial was carried out on 120 patients with mild to moderate vascular dementia choline intake: work.