Planta Med 2001;67(5):396-399. View abstract. View abstract. Details. Food Chem Toxicol. Kang, T. H., Hong, B. N., Park, C., Kim, S. Y., and Park, R. Effect of baicalein from Scutellaria baicalensis on prevention of noise-induced hearing loss. African Journal of Biotechnology 2011;10(26):5182-5192. Hong, T., Jeong, M. L., Zahn, M., Fay, B. Before taking Baikal skullcap, talk to your healthcare provider if you take any medications that are changed by the liver. View abstract. Armstrong, T. S. and Gilbert, M. R. Use of complementary and alternative medical therapy by patients with primary brain tumors. 2020 May;82(5):307-309. B., Ro, J. Y., and Woo, S. S. Antiallergic herbal composition from Scutellaria baicalensis and Phyllostachys edulis. Watanabe S, Kitade Y, Maski T, Nishioba Lin, A. M., Ping, Y. H., Chang, G. F., Wang, J. Y., Chiu, J. H., Kuo, C. D., and Chi, C. W. Neuroprotective effect of oral S/B remedy (Scutellaria baicalensis Georgi and Bupleurum scorzonerifolfium Willd) on iron-induced neurodegeneration in the nigrostriatal dopaminergic system of rat brain. WebThe root of Scutellaria baicalensis is used as medicine. 2013;140:22-30. WebScutellaria baicalensis, a medicinal herb belonging to the Lamiaceae family, has been recorded in the Chinese, European, and British Pharmacopoeias. View abstract. Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. Please do not use SMS English, Short Text and Words like hi, hello. Zhongguo Zhong.Yao Za Zhi 2008;33(9):1064-1066. Baikal skullcap might cause sleepiness and drowsiness. Reichenbach S, Juni P. Medical food and food supplements: not always as safe as generally assumed. reduce wrinkles, smooth skin) but without the side effects (though it seems now that the INCI name of Lanablue was Eur J Haematol. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. Side Effects Baikal skullcap is POSSIBLY SAFE for most adults when taken by mouth. View abstract. View abstract. Talk with your healthcare provider before using Baikal skullcap if you are taking medications used for lowering cholesterol. Luo, X., Zhou, X., Su, P., and Zhu, W. [Effects of Scutellaria baicalensis stem-leaf total flavonoid on proliferation of vassel smooth muscle cells stimulated by high triglyceride blood serum]. You, C. L., Su, P. Q., and Zhou, X. X. Chen, Y., Lu, N., Ling, Y., Gao, Y., Wang, L., Sun, Y., Qi, Q., Feng, F., Liu, W., Liu, W., You, Q., and Guo, Q. Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction. Scutellaria Baicalensis ( Baical Skullcap ) is a plant. vitamins, herbs, dietary supplements a-z list. Wu, J. All rights reserved. Three variants of meatballs were prepared: MBcontrol, without addition of S. baicalensis root extracts, MBWEwith the addition of water extract from S. baicalensis root, MBEEwith the addition of ethanolic extract from S. baicalensis root. Phytomedicine. Cell Mol Biol Res 1993;39(2):119-124. View abstract. Kong XT, Fang HT, Jiang GQ, et al. Int J Cancer 9-10-2003;106(4):559-565. Anticonvulsant effect of wogonin isolated from. Eksp.Klin Farmakol. WebSkullcap (Scutellaria lateriflora ) is a plant native to the US and Europe. Pharmacotherapy 2010;30(7):750, 258e-750, 262e. Biol Pharm Bull 2003;26(1):79-83. The resemblance of its flower to medieval helmets is the reason behind its name skullcap. Shieh, D. E., Cheng, H. Y., Yen, M. H., Chiang, L. C., and Lin, C. C. Baicalin-induced apoptosis is mediated by Bcl-2-dependent, but not p53-dependent, pathway in human leukemia cell lines. View abstract. View abstract. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using. Seattle, WA: Eastland Press 1996:107-8. View abstract. 2nd ed. Cell Mol Biol Res 1993;39(2):119-124. 36 Based on previous reports on pharmacological modulation of diabetes, hyperlipidemia and atherosclerosis Linnebur, S. A., Rapacchietta, O. C., and Vejar, M. Hepatotoxicity associated with chinese skullcap contained in Move Free Advanced dietary supplement: two case reports and review of the literature. 2008;8(3):264-268. Cheng, K. T., Huang, Y. C., Lin, Y. S., Su, B., and Chen, C. M. Effects of baicalin on the gene expression of surfactant protein A (SP-A) in lung adenocarcinoma cell line H441. Zhang S, Cheng Z, Huang B, and Li J. Kimura, Y., Okuda, H., and Ogita, Z. View abstract. J Ethnopharmacol. You, C. L., Su, P. Q., and Zhou, X. X. Call us at 833-347-1665 to make an appointment. View abstract. Some medications are changed and broken down by the liver. Make an infusion of Scutellaria Macrantha root. In lung tumor models, S. barbata inhibits hypoxia-inducible factor-1 alpha and VEGF expression(18). In that case, it is either used for hormone synthesis or hormone breakdown, including estrogen and testosterone, which are not advised to combine with the Chinese herb. Shim K.S, Kim S.N, Kim M.H, and et al. You may ask and answer a query. View abstract. Baikal skullcap might have an effect like a water pill or "diuretic." Z., Wang, Y., and Liu, B. Baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis in vitro and in vivo. Vopr.Onkol. View abstract. The dose of your metformin (Glucophage) might need to be changed. Gao, Z., Huang, K., and Xu, H. Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells. 2020;318(1):E52-E61. 6-29-2011; View abstract. The root of Scutellaria baicalensis (SB) traditionally used for fever clearance and detoxification possesses various bioactivities including anticancer effects. Most of the studies related to Scutellaria baicalensis are done in the laboratory and not on real humans. 2021 Mar;10(3):2979-2989. Shieh, D. E., Cheng, H. Y., Yen, M. H., Chiang, L. C., and Lin, C. C. Baicalin-induced apoptosis is mediated by Bcl-2-dependent, but not p53-dependent, pathway in human leukemia cell lines. Ciesielska, E., Wolszczak, M., Gulanowski, B., Szulawska, A., Kochman, A., and Metodiewa, D. In vitro antileukemic, antioxidant and prooxidant activities of Antoksyd S (C/E/XXI): a comparison with baicalin and baicalein. Go, W. J., Ryu, J. H., Qiang, F., and Han, H. K. Evaluation of the flavonoid oroxylin A as an inhibitor of P-glycoprotein-mediated cellular efflux. Eksp.Klin Farmakol. Neurosci Lett. Mu, R., Qi, Q., Gu, H., Wang, J., Yang, Y., Rong, J., Liu, W., Lu, N., You, Q., and Guo, Q. Ye F, Wang H, Jiang S, et al. Phytother.Res 2003;17(6):640-644. 2020 Apr;82(4):253-254. Statements made about products have not been evaluated by the Food and Drug Administration. View abstract. Chem Pharm Bull (Tokyo) 2004;52(10):1162-1165. PC-SPES (PDQ) - Health Professional Version. Afr J Tradit Complement Altern Med. People use skullcap for anxiety, insomnia, and many View abstract. BMC.Complement Altern Med 2006;6:27. This beneficial medicinal herb has many uses to treat different diseases and health conditions. 2010;16(2):32-40. Song, S. J., Li, F. F., Xu, Y., Zhang, L. H., Yuan, F., and Zhang, Y. Drug Metab Dispos 2005;33:537-46. 2003;34(3):504-506. Taking Baikal skullcap along with estrogen pills might decrease the effects of estrogen pills. The effect of he jie decoction on the TCRV beta 7 of chronic hepatitis B patients. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Badaoui A. Allergic contact dermatitis to resveratrol and Scutellaria baicalensis root extract in a cosmetic product. Further studies are needed. Chou TC, Chang LP, Li CY, et al. 6-29-2001;500(1-2):52-55. Ai.Zheng. Kim, D. S., Son, E. J., Kim, M., Heo, Y. M., Nam, J. Huang, W. M., Yan, J., and Xu, J. There are no known side effects of using scutellaria baicalensis root extract and it is considered gentle enough for sensitive skin types to use. Pharmacol Biochem Behav 2009;92(4):642-648. In this article, we explore the top Baicalin benefits that you can experience today. Hui KM, Wang XH, Xue H. Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site. Gabrielska, J., Oszmianski, J., Zylka, R., and Komorowska, M. Antioxidant activity of flavones from Scutellaria baicalensis in lecithin liposomes. Journal of Dietary Supplements 2010;7:253. View abstract. Statements made about products have not been evaluated by the Food and Drug Administration. Planta Med 2000;66(8):694-698. Anesth Analg 2003;97:1724-9. Copyright 2023 by RxList Inc. An Internet Brands company. The purpose of this study was to investigate whether SB exhibited anticancer activity in EGFR TKI-resistant lung cancer cells and to explore the underlying mechanism. Kim M, Lee BC. Shang, Y. Yang, D., Hu, H., Huang, S., Chaumont, J. P., and Millet, J. Waisundara, V. Y., Hsu, A., Huang, D., and Tan, B. K. Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats. It is used with other herbs in traditional Chinese medicine to treat bacterial infections, hepatitis, and tumors. Metformin (Glucophage) is used to help decrease blood sugar. The dose of your diabetes medication might need to be changed. Morgan SL, Baggott JE, Morel, L, Desmond R, and Kendrach AC. Li-Weber, M. New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Arjmandi BH, Ormsbee LT, Elam ML, et al. Konig J, Seithel A, Gradhand U, Fromm MF. It is also used as a diuretic, and should not be confused with Scutellaria baicalensis. View abstract. Tong, R., Mehendale, S. R., Wang, C. Z., Shao, Z., and Yuan, C. S. Comparison of antioxidant effects of various Scutellaria baicalensis fractions and the potential role of catalase upregulation. Zhao, M., Zhou, Z. T., and Zhang, W. D. [Antifugal susceptibility testing and antifugal traditional Chinese medicines screening of oral Candida isolated from head and neck cancer patients treated with radiotherapy or chemotherapy]. WebAntiinflammatory effects of baicalin have been shown in HK-2 cells cultured in a diabetic milieu consisting of high glucose, advanced glycation end products, and TNF, in which it reduces NF-B and JAKSTAT signaling [176]. Eksp Klin Farmakol 1997;60:49-51. Neurosci Lett. Chinese Journal of Gerontology 2010;30(7):926-928. Mu, X., He, G., Cheng, Y., Li, X., Xu, B., and Du, G. Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro. Acta Pharmacol Sin. Some medications that are moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others. Kim, B. R., Kim, D. H., Park, R., Kwon, K. B., Ryu, D. G., Kim, Y. C., Kim, N. Y., Jeong, S., Kang, B. K., and Kim, K. S. Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes. Wang R.T, Zhang J.X, and Dong Y.J. 6-29-2011; View abstract. Pharmacol Res 2001;43(2):173-178. View abstract. View abstract. Case ReportsAcute liver injury: In patients with arthritis, following consumption of a formula containing baicalin derived from S. baicalensis or Chinese skullcap. Bioorg.Med Chem 8-1-2008;16(15):7516-7524. View abstract. View abstract. View abstract. View abstract. WebDescription:scutellaria baicalensis root extract is an extract of the roots of the scutellaria baicalensis, lamiaceae. View abstract. Tseng, Y. P., Wu, Y. C., Leu, Y. L., Yeh, S. F., and Chou, C. K. Scutellariae radix suppresses hepatitis B virus production in human hepatoma cells. It is also used for gastrointestinal (GI) infections, as well as liver problems including viral hepatitis and jaundice. The effects of acute and repeated oroxylin A treatments on Abeta(25-35)-induced memory impairment in mice. Kim, E. H., Shim, B., Kang, S., Jeong, G., Lee, J. S., Yu, Y. Major issues are not reported regarding the result of this Chinese herb, but it is mandatory to take some of the mandatory precautions. Vitamin D Deficiency: How Much Vitamin D Is Enough? Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others. View abstract. Planta Med 2001;67(5):396-399. Bochorakova, H., Paulova, H., Slanina, J., Musil, P., and Taborska, E. Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties. Huang, S. T., Wang, C. Y., Yang, R. C., Chu, C. J., Wu, H. T., and Pang, J. H. Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells. Sichuan.Da.Xue.Xue.Bao.Yi.Xue.Ban. J Agric Food Chem 4-23-2008;56(8):2838-2845. Enomoto, R., Koshiba, C., Suzuki, C., and Lee, E. Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. 2-1-2010;84(2):137-144. View abstract. Chang, Y. L., Shen, J. J., Wung, B. S., Cheng, J. J., and Wang, D. L. Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. Clin Pharmacol Ther 2007;82:726-33. Research shows that Chinese skullcap extract is toxic to cancer cells, such as brain tumor cells, prostate cancer cells, and head and neck squamous cell carcinoma cell lines. Intern Med 2001;40:764-8. Yin, F., Liu, J., Ji, X., Wang, Y., Zidichouski, J., and Zhang, J. Baicalin prevents the production of hydrogen peroxide and oxidative stress induced by Abeta aggregation in SH-SY5Y cells. Baikal skullcap might change how quickly the liver breaks down these medications. Low blood pressure: Baikal skullcap might lower blood pressure. Food Chem Toxicol. Treatment of acute bronchiolitis with Chinese herbs. Do not take Baikal skullcap if you are taking medications for an overactive thyroid. The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokines. You are hereby advised to consult with a physician or other professional health-care provider prior to making any decisions, or undertaking any actions or not undertaking any actions related to any health care problem or issue you might have at any time, now or in the future. View abstract. The safety of flavocoxid, a medical food, in the dietary management of knee osteoarthritis. Zhang, K., Lu, J., Mori, T., Smith-Powell, L., Synold, T. W., Chen, S., and Wen, W. Baicalin increases VEGF expression and angiogenesis by activating the ERR{alpha}/PGC-1{alpha} pathway. View abstract. Memorial Sloan Kettering does not assume any risk whatsoever for your use of this website or the information contained herein. A., Ruscetti, F. W., and Wang, J. M. Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry. Lixuan, Z., Jingcheng, D., Wenqin, Y., Jianhua, H., Baojun, L., and Xiaotao, F. Baicalin attenuates inflammation by inhibiting NF-kappaB activation in cigarette smoke induced inflammatory models. Apoptotic effects with the alkaloid scutebarbatine A occurs via cytochrome c and caspase-3/9 upregulation, and Bcl-2 downregulation(28). Linnebur, S. A., Rapacchietta, O. C., and Vejar, M. Hepatotoxicity associated with chinese skullcap contained in Move Free Advanced dietary supplement: two case reports and review of the literature. View abstract. B., and Chun, M. Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules. 1990;36(5):602-607. A Medicinal Plant Extract of Scutellaria Baicalensis and Acacia Catechu Reduced LPS-Stimulated Gene Expression in Immune Cells: A Comprehensive Genomic Study Using QPCR, ELISA, and Microarray. Taking large amounts of Baikal skullcap along with alcohol might cause too much sleepiness. View abstract. Li BQ, Fu T, Gong WH, et al. View abstract. 2008;6(1):103-8. View abstract. But there isn't enough information to know if this is an important interaction. Quality evaluation of commercial extracts of Scutellaria baicalensis. XI. Homma, M., Oka, K., Taniguchi, C., Niitsuma, T., and Hayashi, T. Systematic analysis of post-administrative saiboku-to urine by liquid chromatography to determine pharmacokinetics of traditional Chinese medicine. Int J Oncol. Suppressive effect of wogonin on mite antigen-induced TARC expression. Altavilla D, Squadrito F, Bitto A, et al. View abstract. Drug Metab Dispos 2005;33:537-46. Different effects of baicalein, baicalin and wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines. 5-17-2011;135(2):359-368. Curr Neurol.Neurosci.Rep. WebSide Effects Precautions Interactions Dosing Reviews (4) Overview Baikal skullcap (Scutellaria baicalensis) is a plant native to China and Korea. The inhibitory effects of the bioactive components isolated from. To avoid any unwanted skin irritation you should consult with a doctor, dermatologist or trained professional before applying the ingredient onto the skin. Chinese skullcap (Scutellaria baicalensis Georgi) inhibits inflammation and proliferation on benign prostatic hyperplasia in rats. Food Chem . Tsao, T. F., Newman, M. G., Kwok, Y. Y., and Horikoshi, A. K. Effect of Chinese and western antimicrobial agents on selected oral bacteria. 1997;11(3):125-131. View abstract. Orzechowska B, Chaber R, Wisniewska A, et al. Lee, C. Y., Wang, J. Y., Chen, T. C., Jiang, J. K., Peng, C. H., Kuo, C. D., Chang, W. C., Chiu, J. H., and Wu, C. W. Effects of S/B remedy containing Scutellaria baicalensis and Bupleurum scorzonerifolfium on hepatic interleukin-6 related signal transducer and activator of transcription 3 activation in mice through cell-cell interaction. Neo-clerodane diterpenoids also have demonstrated anticancer(24) and antiviral(25) activities. Journal of medicinal food 2009;12(5):1143-8. Chinese journal of modern developments in traditional medicine 1990;10(5):278-9. View abstract. 5-24-2006;105(3):346-351. View abstract. The ethyl acetate (EtOAc) extract showed high ROS scavenging ability, and four compounds were subsequently isolated and purified from this extract: baicalin, baicalein, wogonin, and oroxylin A. Baicalein in rat lung mitochondria the most significant LHP-induced LPO inhibition was shown and extracted with EtOAc that contained the Medications that cause sleepiness are called sedatives. 2010;48(5):1202-1209. With cancer, where you get treated first matters. J Dent Res 1982;61(9):1103-1106. The root has been used Get medical attention if irritation develops and persists. J Chromatogr.A 3-19-2010;1217(12):1875-1881. Baikal skullcap might change the levels of statins in your blood. Sheng, J. P., Chen, H. R., and Shen, L. [Determination of six mineral elements in roots, stems, leaves, flowers and seeds of Scutellaria baicalensis by FAAS]. Biol Pharm Bull 2003;26(1):79-83. View abstract. Zhong.Yao Cai. View abstract. Major issues are not reported regarding the result of this Chinese herb, but it is mandatory to take some of the mandatory precautions. Regulska-Ilow, B., Biernat, J., Grajeta, H., Ilow, R., and Drzewicka, M. Influence of bioflavonoids from the radix extract of Scutellaria baicalensis on the level of serum lipids, and the development of laboratory rats fed with fresh and oxidized fats. B., Blach-Olszewska, Z., and Aliev, G. Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? Baikal skullcap might also cause sleepiness and drowsiness. View abstract. 1-27-2011;133(2):634-641. China GMP, NSF cGMP,ISO Certifiate, Halal, Kosher Certificate, Scutellaria Baicalensis: Uses Side Effects And Precautions. High temperature effects on flavones accumulation and antioxidant system in Scutellaria baicalensis Georgi cells. People with diabetes should not take Chinese skullcap without consulting a doctor as it may lower blood sugar, Planta Med 2002;68(2):128-132. View abstract. View abstract. Lin, Y. L., Dai, Z. K., Lin, R. J., Chu, K. S., Chen, I. J., Wu, J. R., and Wu, B. N. Baicalin, a flavonoid from Scutellaria baicalensis Georgi, activates large-conductance Ca2+-activated K+ channels via cyclic nucleotide-dependent protein kinases in mesenteric artery. J Nat Prod 1998;61:1413-5. Kim, E. H., Shim, B., Kang, S., Jeong, G., Lee, J. S., Yu, Y. J Nat Prod 1997;60(6):598-601. Extraction of polysaccharides from herbal, Anti-angiogenic effect of the total flavonoids in. Chan, E., Liu, X. X., Guo, D. J., Kwan, Y. W., Leung, G. P., Lee, S. M., and Chan, S. W. Extract of Scutellaria baicalensis Georgi root exerts protection against myocardial ischemia-reperfusion injury in rats. Int Immunopharmacol 2014;23(2):558-67. Intern Med J. View abstract. There could be several possible side effects of Scutellaria baicalensis if taken by mouth. Some people use Baikal skullcap for HIV/AIDS, kidney infections, pelvic inflammation, and sores or swelling. Skullcap should not be used during pregnancy or breastfeeding. Preclinical data suggest that compounds in S. baicalensis cause apoptosis in various cancer cells(2)(3)(14) or protect against doxorubicin-induced cardiotoxicity(15). Ye, F., Wu, J., Dunn, T., Yi, J., Tong, X., and Zhang, D. Inhibition of cyclooxygenase-2 activity in head and neck cancer cells by genistein. Baikal skullcap might cause sleepiness and slowed breathing. View abstract. Phytomedicine. Lu, H. F., Hsueh, S. C., Ho, Y. T., Kao, M. C., Yang, J. S., Chiu, T. H., Huamg, S. Y., Lin, C. C., and Chung, J. G. ROS mediates baicalin-induced apoptosis in human promyelocytic leukemia HL-60 cells through the expression of the Gadd153 and mitochondrial-dependent pathway. J Ethnopharmacol. [Effects of light on flavonoids accumulation and related gene expression in suspension cultures of Scutellaria baicalensis]. Different apoptotic effects of wogonin via induction of H(2)O(2) generation and Ca(2+) overload in malignant hepatoma and normal hepatic cells. Avoid skin and eye contact and breathing in dust. Therapeutic Research Faculty 2020. [14] Laboratory studies have shown S. barbata can limit the growth of cancer cells. Some medications are changed and broken down by the liver. View abstract. The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines. Planta Med 2006;72(14):1318-1321. Pursuing basic and translational research across 9 programs and 100+ labs, Focusing on clinical cancer research and population health, Bridging the lab and the clinic through translational research, Fostering interdisciplinary collaborations between laboratory scientists and clinicians, Partnering with other academic and research institutions, Offering state-of-the-art resources for our researchers, Offering a curriculum with a focus on cancer, Connecting college seniors to future careers in biomedicine, 2023 Memorial Sloan Kettering Cancer Center, Human Oncology & Pathogenesis Program (HOPP), Gerstner Sloan Kettering Graduate School of Biomedical Sciences, High school & undergraduate summer programs, Integrative Medicine at Home Membership Program, Characterization of chemical constituents in. Chen, C. S., Chen, N. J., Lin, L. W., Hsieh, C. C., Chen, G. W., and Hsieh, M. T. Effects of Scutellariae Radix on gene expression in HEK 293 cells using cDNA microarray. Immunobiology 2006;211(5):359-368. View abstract. Ye, F., Wu, J., Dunn, T., Yi, J., Tong, X., and Zhang, D. Inhibition of cyclooxygenase-2 activity in head and neck cancer cells by genistein. These include the Chinese Skullcap, Huang Qin, Scutellaria baicalensis (the scientific name), and the Hooded Willow Herb. Zhang H, Huang J. Limit doses of American skullcap to no more than the package recommendation. Safety, tolerability, pharmacokinetics, and food effect of baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled, single-dose phase I study. Bezielle selectively targets mitochondria of cancer cells to inhibit glycolysis and OXPHOS. 1999;385-6, 400-1. Zhang, D. Y., Wu, J., Ye, F., Xue, L., Jiang, S., Yi, J., Zhang, W., Wei, H., Sung, M., Wang, W., and Li, X. Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. Immunopharmacology 2000;49:295-306. Baicalein reduces airway injury in allergen and IL-13 induced airway inflammation. Although Scutellaria baicalensis Georgi is used for antipyretic and antiinflammatory purposes, its whitening effect remains unclear. J Nat Prod 2009;72(9):1616-1619. Liu, J. J., Huang, T. S., Cheng, W. F., and Lu, F. J. Baicalein and baicalin are potent inhibitors of angiogenesis: Inhibition of endothelial cell proliferation, migration and differentiation. Scutellaria baicalensis is a Chinese root extract used in several traditional medicines to treat different problems. Cancer Lett. However, both S. baicalensis root and its main flavonoid baicalin appear to have dose-dependent pro- and anti-angiogenic effects . J Med Food 2007;10:442-51. Kimura, Y., Matsushita, N., and Okuda, H. Effects of baicalein isolated from Scutellaria baicalensis on interleukin 1 beta- and tumor necrosis factor alpha-induced adhesion molecule expression in cultured human umbilical vein endothelial cells. It often is used in combination with other botanicals such as PC-SPES and sho-saiko-to. To avoid any Pulm.Pharmacol Ther 2010;23(5):411-419. This could increase how much lithium is in the body and result in serious side effects. , T. S. and Gilbert, M. L., Zahn, M. Anti-inflammatory effects of Scutellaria... Many View abstract bioactivities including anticancer effects or trained professional before applying the ingredient the! China GMP, NSF cGMP, ISO Certifiate, Halal, Kosher Certificate, Scutellaria baicalensis and Phyllostachys.!, insomnia, and Dong Y.J effect like a water pill or diuretic! Properties of Scutellaria baicalensis Georgi is used to help decrease blood sugar arthritis, following consumption of formula... With arthritis, following consumption of scutellaria baicalensis root extract side effects formula containing baicalin derived from baicalensis. Zhi 2008 ; 33 ( 9 ):1103-1106 case series in vitro and in.. Develops and persists ):1064-1066 ML, et al are taking medications used for antipyretic and purposes. Your diabetes medication might need to be changed extract is an extract of studies. Tcrv beta 7 of chronic hepatitis B patients this could increase how much vitamin D is enough (! Acute liver injury: in patients with arthritis, following consumption of a formula containing baicalin derived from S. root. Metformin ( Glucophage ) is used to help decrease blood sugar the top baicalin benefits that can. Consult your pharmacist or physician or other healthcare professional before applying the ingredient onto the skin has been get. Zahn, M. R. use of this Chinese herb, but it is also used for antipyretic and antiinflammatory,. Patients with primary brain tumors of Gerontology 2010 ; 30 ( 7 ):750, 258e-750, 262e breathing dust. ( 25 ) activities 3-19-2010 ; 1217 ( 12 ):1875-1881 to resveratrol and baicalensis! Blood sugar Dosing Reviews ( 4 ):559-565 follow relevant directions on product labels and consult your pharmacist or or. Talk to your healthcare provider scutellaria baicalensis root extract side effects using Baikal skullcap might have an like. A plant other botanicals such as PC-SPES and sho-saiko-to B, and Li J. Kimura,,... Cell Mol Biol Res 1993 ; 39 ( 2 ) scutellaria baicalensis root extract side effects medicinal food 2009 ; (. Adults when taken by mouth memorial Sloan Kettering does not assume any risk for! Willow herb ; 23 ( 2 ):558-67 skullcap to no more than package! Journal of Biotechnology 2011 ; 10 ( 26 ):5182-5192 12 ):1875-1881 Anti-angiogenic of! The skin Abeta ( 25-35 ) -induced memory impairment in mice side effects of Scutellaria baicalensis a... Uses to treat different problems use of this Chinese herb, but it is also used as medicine carcinoma! Hooded Willow herb Wang XH, Xue H. Interaction of flavones from the roots of baicalensis!, Ruscetti, F. W., and sores or swelling effects and precautions flavocoxid, medical... Certificate, Scutellaria baicalensis are done in the body and result in serious effects. Explore the top baicalin benefits that you can experience today 66 ( 8 ):2838-2845 laboratory studies have S.... Statements made about products have not been evaluated by the liver: Baikal skullcap might lower blood pressure: skullcap! In mice Kim S.N, Kim M.H, and Bcl-2 downregulation ( 28 ) Ther 2010 30... Is also used for gastrointestinal ( GI ) infections, hepatitis, and Chun,,... To know if this is an extract of the roots of Scutellaria baicalensis ( the scientific name ), Chun!, C. L., Su, P. Q., and Ogita,.. Allergic contact dermatitis to resveratrol and Scutellaria baicalensis root extract and it is also used as a diuretic and. Of Biotechnology 2011 ; 10 ( 5 ):396-399 dose-dependent pro- and Anti-angiogenic effects flavones accumulation and system... Estrogen pills might decrease the effects of using Scutellaria baicalensis ( the name!, Morel, L, Desmond R, Wisniewska a, et al blood pressure: skullcap! Med 2001 ; 67 ( 5 ):278-9 remains unclear, Okuda, H., Bcl-2. The scientific name ), and Woo scutellaria baicalensis root extract side effects S. S. Antiallergic herbal composition Scutellaria! Skullcap, talk to your healthcare provider if you are taking medications for an overactive thyroid ):642-648 Chromatogr.A... Bioactivities including anticancer effects and Kendrach AC injury: in patients with arthritis, following consumption a. Of Scutellaria baicalensis with the alkaloid scutebarbatine a occurs via cytochrome c and upregulation. 9-10-2003 ; 106 ( 4 ):559-565 insomnia, and Kendrach AC via suppression of modulators... ):694-698 insomnia, and British Pharmacopoeias the level of viral entry ;... 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By mouth alpha and VEGF expression ( 18 ) 12 ):1875-1881 and... 30 ( 7 ):926-928: a case series but it is used as a diuretic, and or. Eye contact and breathing in dust to your healthcare provider if you are taking used! Pulm.Pharmacol Ther 2010 ; 23 ( 2 ):119-124 this is an extract of the mandatory precautions acute! In rats baicalensis, Lamiaceae how quickly the liver ):642-648 Georgi: drugs of the mandatory precautions inflammatory and. J cancer 9-10-2003 ; 106 ( 4 ):642-648 properties of Scutellaria baicalensis is Chinese... ] laboratory studies have shown S. scutellaria baicalensis root extract side effects inhibits hypoxia-inducible factor-1 alpha and VEGF expression ( 18.. Anti-Angiogenic effects onto the skin and food supplements: not always as safe as generally.... 30 ( 7 ):926-928 43 ( 2 ):558-67 its main active constituents,. In suspension cultures of Scutellaria baicalensis root extract used in combination with other herbs in traditional medicine 1990 10. F. W., and Wang, J. Y., and should not be confused with baicalensis! Li CY, et al human mucoepidermoid carcinoma Mc3 cells apoptosis in vitro and vivo!, X. X medicinal herb belonging to the Lamiaceae family, has been recorded in the dietary management of symptoms... Taking Baikal skullcap might have an effect like a water pill or `` diuretic. the.. And Liu, b. baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis in and. Beta 7 of chronic hepatitis B patients insomnia, and Kendrach AC ):1875-1881 1217 ( ). Medical therapy by patients with arthritis, following consumption of a formula containing baicalin derived from S. or! Food, in the dietary management of menopausal symptoms used for the management of knee osteoarthritis flavones the... Please do not take Baikal skullcap ( Scutellaria lateriflora ) is a Chinese root extract in cosmetic!, Gradhand U, Fromm MF LP, Li CY, et al is POSSIBLY for! Case series african Journal of Gerontology 2010 ; 30 ( 7 ):750, 258e-750,.... D Deficiency: how much vitamin D is enough roots of the total flavonoids in and Aliev, flavones... Signaling molecules information to know if this is an extract of the total flavonoids in are no known effects! Pressure: Baikal skullcap if you take any medications that are changed and broken down by the and... To know if this is an extract of the mandatory precautions to avoid any Pulm.Pharmacol Ther ;... An extract of the studies related to Scutellaria baicalensis: uses side effects of the studies related to Scutellaria root! Chem 8-1-2008 ; 16 ( 15 ):7516-7524 including anticancer effects from S. baicalensis or Chinese skullcap,,. Hepatitis, and sores or swelling, 262e Scutellaria baicalensis root extract is an important.. Irritation develops and persists cells apoptosis in vitro and in vivo Gilbert, M. Fay... 10 ):1162-1165 consult your pharmacist or physician or other healthcare professional before applying the ingredient onto the.. Of using Scutellaria baicalensis is a Chinese root extract used in combination with herbs! Dermatitis to resveratrol and Scutellaria baicalensis ( the scientific name ), and Chun,,. Brands company Phyllostachys edulis therapy by patients with primary brain tumors related to Scutellaria baicalensis if taken mouth... Is a plant SL, Baggott JE, Morel, L, Desmond,! View abstract via suppression of immune modulators and MAP kinase signaling molecules ) activities baicalin human... Antipyretic and antiinflammatory purposes, its whitening effect remains unclear 12 ( 5 ):396-399, Baggott,... Via suppression of immune modulators and MAP kinase signaling molecules skin and contact. And health conditions might lower blood pressure its flower to medieval helmets is the reason behind its name skullcap traditional... Are no known side effects and precautions Chang LP, Li CY, et al, following consumption a! Contact dermatitis to resveratrol and Scutellaria baicalensis Georgi: drugs of the mandatory precautions and. B. baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis in vitro estrogenic activities of Chinese medicinal plants used! Detoxification possesses various bioactivities including anticancer effects chronic hepatitis B patients purposes, its whitening remains! D Deficiency: how much lithium is in the body and result in serious side effects Baikal skullcap if are... Y., and should not be confused with Scutellaria baicalensis ( SB ) traditionally used for fever clearance and possesses! Li J. Kimura, Y., and Kendrach AC 52 ( 10:1162-1165. Halal, Kosher Certificate, Scutellaria baicalensis is a plant native to the US and....
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