For example, in one small placebo-controlled study10, individuals who took a supplement with astaxanthin for 12 weeks experienced improved memory and cognition. J Dermatol Sci 2010;58(2):136-142. What are the risks of taking astaxanthin? View abstract. The amount of astaxanthin found in whole food sources is generally safe and can be consumed with minimal risk of side effects. View abstract. Other natural food sources of astaxanthin include shrimp, crayfish, krill, trout, yeast and algae. Antioxidants, including astaxanthin, have been shown to support female hormones by cleaning up oxidative stress. * However, it might be time to add another antioxidant to the list. In fact, its responsible for the red and pink colors of salmon and algae. . Jyonouchi H, Sun S, Iijima K, Gross MD. It may also help protect against kidney damage from diabetes. View abstract. View abstract. Liu, X., Yamada, N., and Osawa, T. Assessing the neuroprotective effect of antioxidant food factors by application of lipid-derived dopamine modification adducts. It is also available through many online retailers if you have trouble finding it in your area. As one of the most potent carotenoids and antioxidants found in nature, astaxanthin benefits many aspects of health, from diminishing wrinkles to upgrading your workout routine. But what makes astaxanthin so special, exactly? *) After all, it's not a competition. That way, your doctor can check on any potential side effects or interactions with any medications. Bennedsen M, Wang X, Willen R, et al. Arch Ophthalmol 2008;126(10):1396-1403. View abstract. Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players. A subtype of free radicals called reactive oxygen species can disrupt the normal process of the kidneys and lead to some not-so-good outcomes. An animal study in 2014 showed the astaxanthin group delayed time to exhaustion in a swimming test by 29%. View abstract. Coconut oil, avocados, walnuts and beets are just a few examples of other brain foods that boost focus and memory. Carotenoid Sci. BPA is a common chemical found in hard plastics that can disrupt female hormone production. View abstract. Plant Foods Hum Nutr. Primarily found in seafood, there are a variety of ways for you to get in plenty of this beneficial antioxidant. Chitchumroonchokchai, C., Bomser, J. However, the synthetic astaxanthin may not be quite as stellar for your health. It's unclear what effect this may have, but prescription medicines that affect the same enzyme may cause side effects, such as: One small study showed astaxanthin combined with saw palmetto actually increased testosterone, which could help libido. We know that carotenoids are antioxidants and may have certain health benefits. Many studies have found that astaxanthin can reduce markers of inflammation in the body. Electronic Code of Federal Regulations. A Scientific Guide to This Powerful Supplement, 5 Vitamins and Supplements For Energy and Fatigue 2023. An animal? View abstract. The more diverse our nutrient and phytonutrient intake and array are, the better. View abstract. Risks. It's also available in natural supplement form. Astaxanthin is a type of carotenoid found naturally in wild-caught salmon and other seafoods and green algae. The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. Kirsten Nunez is a health and lifestyle journalist based in Beacon, New York. 2012;59(1):43-47. It has an exceptionally unique chemical makeup, allowing it to neutralize free radicals at a higher rate than other carotenoids4. Plasma appearance of unesterified astaxanthin geometrical E/Z and optical R/S isomers in men given single doses of a mixture of optical 3 and 3'R/S isomers of astaxanthin fatty acyl diesters. . Side Effects and Toxicity Because astaxanthi influences hormonal changes one should be aware that it might negatively interact with some hormone-altering medications. Astaxanthin is a carotenoid and very high intakes of carotenoids can cause your skin to turn orange. Many people think of lutein as "the eye vitamin." Lutein is one of two major carotenoids . No problem! The only problem? Note that astaxanthin is only included in the Women's Balance supplement. View abstract. J Photochem.Photobiol.B 1994;26(3):283-285. Biochem Soc Trans 1990;18(6):1054-1056. A good amount of emerging research has found thatastaxanthin benefits brain health by preserving cognitive function. Initially, its best to start with a low dose and work your way up to assess your tolerance. The effect of astaxanthin supplementation on performance and fat oxidation during a 40 km cycling time trial. Since adequate progesterone levels and other hormone balance levels are essential in females and males, astaxanthin has the potential to be a promising nutrient for a vast amount of people with additional research. One trial suggested that up to 6 mg per day is safe. View abstract. View abstract. That means it helps reduce a natural process in your body called oxidation. Tanaka T, Morishita Y, Suzui M, et al. As you get older, the risk of developing neurodegenerative disorders like Alzheimers or Parkinsons disease continues to increase. Studies on mice show that it can boost the body's use of fatty acids, which helps. These conditions can cause a wide array of symptoms, ranging from blurry vision to complete vision loss. Atherosclerosis 2010;209:520-23. Spirulina is a blue-green alga that naturally grows in salty lakes and oceans in subtropical climates. Ophthalmology 2008;115:324-33. One end of the molecule protects the fat-soluble part of cells. * In fact, its antioxidant activity is 10 times higher than beta-carotene3, earning it titles like "King of Carotenoids" and "super antioxidant molecule" by researchers.*. Studies showed astaxanthin strengthens our retinas against these kinds of oxidative stress, even including eye strain and fatigue, both common after close viewing and prolonged blue light exposure from computer screens. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182. Combined conventional/antioxidant "Astaxanthin" treatment for male infertility: a double blind, randomized trial. Side effects of astaxanthin may include increased.Although studies in humans are limited, there are numerous astaxanthin benefits and side effects to consider that support biological functions. View abstract. Methods Find Exp Clin Pharmacol 2001;23:79-84. The study also found that astaxanthin supported a healthy balance of reproductive hormones. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled study. Nishigaki, I., Rajendran, P., Venugopal, R., Ekambaram, G., Sakthisekaran, D., and Nishigaki, Y. Cytoprotective role of astaxanthin against glycated protein/iron chelate-induced toxicity in human umbilical vein endothelial cells. Is It (Finally) Time to Stop Calling COVID a Pandemic? MF Afragil(R) in the treatment of 34 menopause symptoms: a pilot study. 2003;21(5):210-216. Astaxanthin side effects hormones Some laboratory studies have shown astaxanthin may hinder an enzyme called 5-alpha-reductase. Since it can act as a powerful antioxidant, it could have a protective effect on the kidneys. Astaxanthin is a powerful antioxidant that may help protect cells from damage from oxidative stress. Astaxanthin might help the heart in a number of ways, as well. * And a 2020 study found that due to its antioxidant properties, astaxanthin may support overall cardiovascular health. However, astaxanthin does not appear to cause any significant side effects when taken as directed. J Am Coll Nutr. B., Xu, Y. X., Zhao, H., Zhu, Q. Y., and Zhu, C. Q. Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells. Benefits and Safety of Astaxanthin in the Treatment of Mild-To-Moderate Dry Eye Disease. Canthaxanthin retinopathy. * Research in humans is still ongoing, but the available studies so far have been promising. As a result, it could keep testosterone from changing into the hormone DHT in the body. Toxicities Doses of up to 50mg have been tolerated. Some of its benefits may even come as a complete shock to you. To maximize the absorption and health benefits of astaxanthin, its best to get your daily dose by incorporating whole food sources into your diet. Acta Biochim Pol. J Sci Med Sport. One animal study showed that astaxanthin significantly alleviated the oxidative stress in developing cultured follicles and ovarian cells caused by BPA administration in vivo and in vitro. O'Sullivan, L., Ryan, L., and O'Brien, N. Comparison of the uptake and secretion of carotene and xanthophyll carotenoids by Caco-2 intestinal cells. 2008;9:17. In fact, astaxanthin may help support the health of these body systems. 2017;48:40-48. * Advertisement 3. These are herbs that are commonly used in altering the body's hormone level. View abstract. In addition to boosting brain and heart health, astaxanthin benefits skin health as well. Overall, astaxanthin is a powerful carotenoid with antioxidant properties that can be taken as a dietary supplement that can support your health in numerous ways, including eye health, skin health, immune health, and more. Chemoprevention of rat oral carcinogenesis by naturally occurring xanthophylls, astaxanthin, and canthaxanthin. It occurs naturally in certain algae and causes the pink or red color in salmon, trout, lobster, shrimp, and other seafood. Some laboratory studies have shown astaxanthin may hinder an enzyme called 5-alpha-reductase. A 2010 randomized, controlled trial found that supplementation with astaxanthin increased the immune response of subjects as it also reduced oxidative stress, including one specific marker of DNA damage that could potentially translate to disease later in life. Parisi V, Tedeschi M, Gallinaro G, et al. Other high-antioxidant foodsthat can help relieve inflammation and ward off disease include turmeric, ginger, dark chocolate and blueberries. Wild salmon obtain this carotenoid naturally from their diet of shrimp and small fish. Case in point: According to a 2019 scientific article, it's been used as a supplement for more than two decades, and there are no documented negative side effects to date. The other protects the water-soluble part of cells. Therefore, its best to choose a natural form of astaxanthin! View abstract. Astaxanthin is a reddish pigment that belongs to a group of chemicals called carotenoids. A later study in 2016 also on competitive male cyclists gave evidence to astaxanthins performance-enhancing effect. View abstract. Natural food sources of astaxanthin include marine sources like algae, crayfish, krill, salmon, and shrimp. Video: Why You Need Zinc and Where to Find It. It's. View abstract. McNulty, H., Jacob, R. F., and Mason, R. P. Biologic activity of carotenoids related to distinct membrane physicochemical interactions. These foods are especially beneficial because most provide an array of important nutrients in addition to astaxanthin, such as vitamins, minerals and omega-3 fatty acids. Liver / drug effects* Both the kidney and the liver are essential for detox! View abstract. Food Chem Toxicol. In one animal study, astaxanthin restored both testosterone and progesterone production in leydig cells (found in the testes) exposed to oxidative stress. 2002;8(7):438-441. Mahmoud, F. F., Haines, D. D., Abul, H. T., Abal, A. T., Onadeko, B. O., and Wise, J. One study even showed astaxanthin is 6,000 times stronger than vitamin C! Side Effects With extreme doses (48mg daily) feces may turn a reddish hue due to the red pigmentation of astaxanthin. Astaxanthin is also available in a natural supplement form. Br J Nutr 2007;98(1):38-44. If there is something in the blood that could be harmful to the kidneys, it could have a negative impact on kidney function. View abstract. The greatest attribute of astaxanthin is that it's both a powerful antioxidant and anti-inflammatory. Astaxanthin, or any antioxidant, can help fight against this stress. View abstract. What Are the Benefits of Astaxanthin? View abstract. This should not be a concern, though. But lets first review any potential issues from taking astaxanthin. Trends Biotechnol. 2018;10(3). Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Nutrients 2017;9(4):387. Astaxanthin is a safe antioxidant. Supplement ingredients that are absorbed by the digestive system must pass through your liver. Carcinogenesis 1994;15:15-9. Unlike drug manufacturers, the makers of supplements dont have to show their products are safe or effective before selling them on the market. Information from this source is evidence-based and objective, and without commercial influence. FEMS Immunol.Med Microbiol. View abstract. One of the largest sources of astaxanthin is in certain types of marine algae. Inflammation is an important part of the bodys immune response. Lignell, . Nutrients 2021;13(12):4381. Eur J Nutr. This beauty from within approach will continue to be a daily staple for me*, Cora Q., 2007;50:244-48. There has been a lot of study on how astaxanthin can affect endurance, as well as fatigue levels after exercise. 2004;94(2):129-136. Belcaro G, Cesarone MR, Cornelli U, et al. Also avoid astaxanthin if you're allergic or sensitive to: Women who are pregnant or might become pregnant should avoid astaxanthin. Forum Nutr 2009;61:136-146. Supplement makers may suggest varying amounts of astaxanthin for different purposes. 2008;107(6):1730-1740. A few of the best sources of astaxanthin include: Dont eat these type of fish? Effect of astaxanthin on cycling time trial performance. 2020;67(3):307-316. The clinical trials we will review did not report safety issues. Zhang, X., Zhao, W. E., Hu, L., Zhao, L., and Huang, J. Carotenoids inhibit proliferation and regulate expression of peroxisome proliferators-activated receptor gamma (PPARgamma) in K562 cancer cells. Can you get astaxanthin naturally from foods? Other potential astaxanthin uses include improving skin health and reducing inflammation. Med Sci Sports Exerc. Biochem.Biophys.Res.Commun. Nir, Y., Spiller, G., and Multz, C. Effect of an astaxanthin containing product on carpal tunnel syndrome. According to a 2018 comprehensive review article, it comes down to its molecular structure. If you do experience any negative side effects, consider decreasing your dosage or discontinuing use. View abstract. Hussein, G., Sankawa, U., Goto, H., Matsumoto, K., and Watanabe, H. Astaxanthin, a carotenoid with potential in human health and nutrition. Of course, a healthy diet containing astaxanthin is just one piece of the puzzle. 2005;5(1):17-26. Gharaei R, Alyasin A, Mahdavinezhad F, Samadian E, Ashrafnezhad Z, Amidi F. Randomized controlled trial of astaxanthin impacts on antioxidant status and assisted reproductive technology outcomes in women with polycystic ovarian syndrome. Z Angew Chem 1938; 51: 465-466. Spirulina is rich in a range of vitamins and minerals essential for maintaining a healthy immune system, like vitamins E, C, and B6. Cicero, AF, Rovati LC, and Setnikar I. Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol-lowering agents. As we review the topic of astaxanthin side effects, we will focus on both the positive and any potential negative side effects. Astaxanthin (3,3'-dihydroxy-,'-carotene-4,4'-dione) is a nonprovitamin A carotenoid classified as a xanthophyll and is found in high amounts in the red pigment of crustacean shells (e.g., crabs, shrimp), salmon, trout, and asteroides. Additional research and clinical trials are needed for conclusive results relating to hormones. View abstract. She has a Master of Science in Nutrition from Texas Woman's University and Bachelor of Science in Dietetics from SUNY Oneonta. Astaxanthin delivered as capsules seems to be well tolerated [12]. * The skin benefits of astaxanthin are totally noteworthy, and it's all thanks to its potent antioxidant properties. View abstract. View abstract. It may also play a role in eye and brain health. Are you concerned that astaxanthin may affect your hormones? View abstract. Brown DR, Warner AR, Deb SK, Gough LA, Sparks SA, McNaughton LR. U.S. STD Cases Increased During COVIDs 2nd Year, Have IBD and Insomnia? Overview. 2002;21:489. Am J Cardiol 5-22-2008;101(10A):20D-29D. These conditions, which are characterized by the progressive loss of neurons in the brain, can lead to symptoms like memory loss, confusion, tremors, agitation and anxiety. View abstract. Some of the most commonly reported astaxanthin side effects include: Additionally, because research is limited on the safety of astaxanthin supplements in women who are pregnant or breastfeeding, its best to stay on the safe side and stick to food sources to get your daily dose. Learn how to use astaxanthin to support your health goals. Phytomedicine. Care/ofs astaxanthin supplement provides 6mg per serving of natural astaxanthin, which a review study reported no adverse effects at this daily dosage level and up to 12mg or more per day. *, Carotenoids in general are associated with heart health, and astaxanthin is no exception. 1999;Patent Cooperation Treaty application #9911251, Lignell, . The role of nutritional supplements in the prevention and treatment of resistance exercise-induced skeletal muscle injury. View abstract. View abstract. View abstract. In addition, astaxanthin protects against UV-induced skin deterioration and helps maintain healthy skin in healthy people, according to a randomized, double-blind, placebo-controlled trial in healthy study participants. After all, reducing oxidative stress allows many parts of the body to function more efficiently. Iwamoto, T., Hosoda, K., Hirano, R., Kurata, H., Matsumoto, A., Miki, W., Kamiyama, M., Itakura, H., Yamamoto, S., and Kondo, K. Inhibition of low-density lipoprotein oxidation by astaxanthin. This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. Here are 5 promising benefits and uses of saw palmetto. * Here's how that shakes out in published science: According to a 2021 scientific review, as astaxanthin exerts antioxidant effects, it may also help promote healthy blood pressure8. Astaxanthin from shrimp by-products ameliorates nephropathy in diabetic rats. 2001;(U.S. Patent No. Part 182 -- Substances Generally Recognized As Safe. J Agric Food Chem. If youre getting it from whole food sources, you should try incorporating a few servings of astaxanthin-rich foods into your diet per week. If you are thinking about starting any new dietary supplement, its always a good idea to review the potential negative side effects it could cause. This can happen during a heart attack. View abstract. When it comes to antioxidant supplements, nutrients like vitamin C and vitamin E often steal the show. Learn about its numerous health benefits for the brain, heart, skin, eyes and more. View abstract. This could change the effects and side effects of these medications. Lyons, N. M. and O'Brien, N. M. Modulatory effects of an algal extract containing astaxanthin on UVA-irradiated cells in culture. View abstract. Chalyk NE, Klochkov VA, Bandaletova TY, Kyle NH, Petyaev IM. What Vitamins and Supplements Can Help you Address a Hormonal Imbalance? Crit Rev Food Sci Nutr 2006;46(2):185-196. eat, so a supplement is way more practical. In fact, its ability to fight free radicals has been shown to much higher than vitamin C, vitamin E and beta-carotene. Therapeutic Research Faculty 2020. For example, astaxanthin can hinder the impacts of other dietary supplements and herbs. An animal study found astaxanthin to be beneficial for the healthy aging of ovaries, an important piece of the reproductive system. Nutrients 2022;14(10):2050. Whether youre looking to kick up your workout routine or give your energy levels a boost at the gym, an extra dose of astaxanthin may be able to help. The Effect of Astaxanthin on Oxidative Stress Indices in Patients With Polycystic Ovary Syndrome. With astaxanthin, the danger comes from isolating the stuff, packing it into a pill, and then telling people it will lower their cholesterol and blood pressure. All rights reserved. Yoshida H, Yanai H, Ito K, Tomono Y, et al. A 2nd method to lower astaxanthin side effects is to stop taking substances contraindicated by astaxanthin. View abstract. Carcinogenesis 1998;19:403-11. Doses of up to 20-50mg astaxanthin have been tolerated, although the exact toxicity and upper limit is not known. View abstract. This is especially true when it is esterified, which is the natural form when astaxanthin biosynthesis takes place in microalgae, as displayed in animal studies. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats. Nutrients. As the leading cause of death, heart disease is a major problem around the world. It may also help protect heart muscle from damage from lack of oxygen. Its a pigment that provides pink and red color to foods like salmon and shrimp. So lets examine more aboutastaxanthin and learn how to get the mostastaxanthin benefits you can from your diet. Karppi et al. View abstract. In terms of skin health, astaxanthin promotes evenness in skin tone, helps keep skin moisturized, and shows significant protective benefits against oxidative stress in skin which contributes to premature aging. Weve already discussed that astaxanthin is likely safe and has few side effects when taken as directed. This can reduce hair loss and sometimes promote hair regrowth. Human trials will be needed to find out more. Minimizing your stress levels, getting in plenty of physical activity and cutting out ultra-processed foods are also key factors to keep your heart in tip-top shape.
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