I have noticed that recently he seems to stumble a little from time-to-time. We did skin scrape and they kept saying allergies. Dose. I did and they said they are going to report it to the FDA. The representative for the company says the half life is 16 days. They got him to eat a little the next morning and sent him home. I wish I had seen this post first. I hope these steps will prevent anyone else's pet having to endure this. Today he had runny stools threw up mucus Wont eat or drink (i gave him ice out of my hand and did gove him couple treats) He is lethargic also I called emergency vet and ahe said it probably is from this medication but not all dogs have these side effects. Thank you for giving information on what happened to your dog. Use a collar or topical if you need to. To make dosing easy, it's available for dogs in six sizes based on body weight range: Simparica Trio can be given to dogs with or without food. 2-6 days in vomiting here and there. I gave this for the first time to my hound and about 3 hours later, she was very unsteady on her feet, eyes half shut and then had 4 episodes of breathing rapidly that each lasted 30 seconds or so and all happened within a 30 minute period. These dog training tips will help you get started. Im throwing away the remaining 5 pills and going back to a topical medicine. She's been given this dosage for over a year. What Are The Side Effects Of Simparica Trio For Dogs? Her protein levels dropped to almost nothing and stomach filled with fluid. After her first dose she had diarrhea, vomiting and developed a terrible wheezing hacking cough. If there are enough reports they may have to pull it off the market until further safety tests can be done. I thought maybe it was just a allergy break out which she's never had this long now I'm wondering if she's continuing to have a reaction. Pyrantel pamoate is a nematocide (kills some worms) belonging to the tetrahydropyrimidine class. However, some dog parents prefer to use separate products. We talked with Zoetis (the manufacturer of Simparica) after the FDA's announcement to get some concrete numbers on the frequency of these adverse reactions. Hi, any chance you did a spinal tap? Same thing has happened to my 5 month old puppy after taking simparica. He looked like he was having spasms. Use with caution in dogs with a history of seizures or neurologic disorders. How is your dog now? No more Simperica for my dog! The results are fatal for fleas and ticks but safe for mammals such as your dog. Hes not well..we hope he recovers fully! In other words, they can make it easier to have a seizure in susceptible dogs. A month later, he was at doggie daycare and we picked him up and he was panting frantically. Im a new pet owner and this will sound ignorant Im sure but I had NO IDEA this is how flea meds works and completely trusted my vet who knows my dogs past sensitive history and I was given the drug not even in its package so I could read anything about it but in individual pills. Monday, Tuesday, Wednesday and Thursday he slept all day, was hesitant to get up, wouldn't play with his ball, continued to drink excessively and shivered. Gave my dogs simparica and they both have lost their appetite! I have paid about $500 - $600 to heal the little King, but it's not working. I just wish I could find a vet who honestly loves my animals as much as I do. All is good! I just gave him heartgard and nexgard about 2 weeks with no issues. Im certain that its the simparica. Side effects are uncommon, but may occur in some cases. The FDA considers this level to be "very rare". Pyrantel Pamoate got its approval for the first time by the FDA for the purpose in 1977. UPDATE We had one normal day on Friday. Same here! Hope your dog is doing well .my dog had clear neurological changes after taking Simparica trio .his tounge just hangs out of his mouth now and that was never the case prior to Simparica,also has tremors and shakes he never previously experienced.also major weight gain even though no increase in diet .i decided to take my pet off of simparico even though the vet strongly engouraged we remain on it even though i explained the symptoms and changes I noticed in my pet ! Now we are out thousands of dollars when every event has been triggered by Simparica Trio. Im petrified after reading the comments here. Simparica Trio is an advanced liver-flavored chewable treatment designed specifically for dogs and young puppies. Then he came too . Wednesday morning at 5am she awoke with bloody diarrhea and it turned into just blood. No side effects. She had terrible watery diarrhea and is not interested in eating. I am trying to remain confident that my poor girl will recover. My beautiful boxer lost his appetite after just one dose of Simparica. She is absolutely miserable and we're hoping she makes it. This is not at all his behavior. How do I get this out of his system and what are you using instead? She was being seen by her regular vet and was put on antibiotics. He seems to be out of sorts, staring into space, getting freaked out when he can't see me (I thought he was losing his eyesight). Did the tremors ever stop? Both of them aren't eating like they were. The personality change is what has me most concerned too. It is the flea and tick component that is the problem. But few people read it or think it must be a million to one problem. She had some good days and we were hopeful but ultimately, she steadily declined. He is 80% its been 27 days since 2nd dose of Simparico.hoping we turned the corner! His vet doesn't think it has anything to do with the Trifexis but I cannot help but think it IS because he was just fine the day before I gave it to him! When my puppy was 2 months old he was "gifted" his first dose of Simparica Trio from his vet. There is a petition in Australia to have this drug banned through change.org, which I've signed. She was shaking like she was freezing. The next day, we took him to his vet and had several tests ran (x-rays, bloodwork, etc.). I take her everywhere as I'm terrified of it happening and her dying, we were convinced she was dying. Then I gave it to her again the 3rd month and the same thing happened. My 11 year old mini Aussie has been taking Simparica 1.5 years. The vet does not feel it is due to Simparica but i think it could be. She has been the healthiest, happiest dog. I hate that I did this to her and I hate that the Vet does not seem to care. If not, we had some success with symptom management using Prednisone. I went to banfield hospital and they prescribed this medication for my dog and had thrown up non stop since he was given the pill and wouldnt eat anything and he passed away 10 days later (yesterday). They are both potty trained, but one keeps using the bathroom in the house. I gave my 10 year old Bull Terrier a dose of Simparico Trio Thursday December 3. Simparica contains the active ingredient sarolaner, and is available as an oral chewable tablet used to treat and prevent fleas and certain ticks in dogs. For Instance he has never liked grooming, I brushed him out last night and he slept through the whole thing. my vet recommended this for both my yorkies. The company is reimbursing for vet costs. So you can imagine my worry now. Do not give extra or double doses. I only stumbled on the side effects of this drug via a post on a Spinone group. Thank you to all of you posting and I hope all of your babies are doing well. Has anyone experienced cardiac issues while under anesthesia on this medication? For those who lost their dear companions from this medicine my heart goes out to you all. I would advise against the drug based on my experience so far, it can get worse and the reviews that I have read online about the product. They did a blood test (this is literally 7 days later) and his ATL liver levels were off the charts at >2000. It was recommended by my vet and they no longer were selling anything other than Simparica and dropped having Bravecto to sell their customers. Will this ever get better as the med wears down? They gave him a strong shot of prednisone that was good for 2 days . Sarolaner is ingested by fleas and ticks when they bite, and works by over-exciting their nervous system, causing paralysis and death. I hope it is taken off the market and request that anyone on this thread with a pet who has suffered due to this drug goes to this link from the FDA to officially report their pet's adverse side effects: https://www.fda.gov/animal-veterinary/report-problem/how-report-animal-drug-side-effects-and-product-problems. (Ours never did, she died 4 months later.) We gave Simparica two days ago and he's not had an appetite, he's eating grass, is drinking a lot of water and sleeping. If you give your dog or cat the flea and tick preventatives Bravecto, Nexgard, Simparica, or Credelio, the FDA wants you to be aware that these medications may cause neurological issues like stumbling, seizures, and twitching in your pet.Though these products are FDA-approved, data received by the agency as part of its post-marketing activities showed the potential for adverse neurological . Simparica uses Sarolaner, which works by overstimulating the nervous system of the pests. The most common Simparica Trio for dogs side effects are; Lethargy Vomiting Diarrhea Loss of appetite Polydipsia Polyuria Hyperactivity Hyperactivity, polydipsia, and polyuria happened in very rare cases. It's not worth the risk of additional seizures or other neurological effects, and it seems that his stumbling and getting tired sooner on walks are likely related. Im so terribly sorry about your puppy. Them I took him to a vet for check up and to my horror, he has fleas and a tick. I am so mad at myself for letting the vet talk me into this. Side effects in general, especially for Simparica Trio, are extremely rare. Heartworm medicine alone should be ok. Oh my god I'm so glad I found this group. Never happened before. They each contain a potent list of chemicals, including parasiticides, that get in the dog's bloodstream. She had what seemed like a seizure 6 hours after ingesting this product--she was lying in her crate, she peed while lying down, and she vomited, then began rocking back and forth--and now I am terrified for her (it's Saturday, nearly midnight, so tomorrow is Sunday and everything is closed). A dog fence is an important detail to consider when adopting a pet for the first time or moving your dog to a new home. The following day he would not even drink water. Head down, facing the wall, tremors, lethargic, and she can't seem to see well. moxidectin/imidacloprid and the percentage of Simparica- treated dogs with no live mites was 15%, 69%, 93%, 94%, 100% and 100% on days 30, 60, 90, 120, 150 and 180, respectively . How did your baby do please? my dog became extremely itchy all over her body. Hi, Id like to thank all the contributors to this thread and Im so very sorry for the pain you and your pets have undergone. I am so mad at myself and so upset that I am the one that has made him sick. We go for more bloodwork today and are praying for better news. With Entyce she is getting her appetite back and seems a little better. Especially after seeing these post. This happened to our 2yr old frenchie last Friday. He had kidney failure he had seizures he had nervous system problems. She's wobbly on her feet and seems lopsided, although her eyes look ok; she is really lethargic and barely lifting her head. Never again will I be giving my pets any pharma meds. Generally, they may instruct you to administer it immediately when you remember and resume monthly dosing. I am interested in the petition and the company's response. The other has had diarrhea every since 6 hours after the pill. How is your dog doing? I should have kept with my gut feeling about any of these oral meds. Seizure meds arent working. As I said, the first was a week after taking it, then the 2nd and third seizure happened at day 29. Please anyone let me know if there is a class action law suit or where we can start one? Sarolaner is effective against the following tick species: Moxidectin is an antiparasitic drug in the macrocyclic lactone class. I have had German Shepherds for 40 yrs. Topical only for me from now on. Doing better now, 2 days later. I have already had a bad experience with "k9 advantix", so I refuse to buy over the counter drugs for my 13 week old Auggie. My sincere sympathies to those with horrendous seizure side effects. I took her home. Is Simparica only available with a prescription? He also lashes at me with his teeth. Simparica and Simparica Trio are available by prescription only. I'm totally stopping the drug, but, unfortunately, can't get in to my vet for almost a month to get a replacement. I'll continue to watch her. For me, Simparica Trio has made parasite control effective and easyI just give her one chewable tablet each month. Thanks all for sharing your experiences. Bravecto 18. This medication must really be strong to do Flea tic and heart worm etc. This medication works within the first few hours after administration to kill fleas present on your dog, and is dosed by weight, so it is important to use the correct-sized medication for your pet. This drug needs to be pulled off the market! So I did. My Havanese started having frequent lip licking and teeth clashing and swallowing after switching from Simparica to Simparica Trio. He is also running a fever so is not out of the woods. They told us he had likely ingested marijuana- despite us having no marijuana in the home and him being supervised on walks. I do believe it caused her blindness. Kristine, unfortunately my sweet Dolly passed away on October 9th. The Maltese mix is lethargic and wont jump on bed or couch. The vet told me to switch to Simparica trio after they stopped seeking revolution which he had been on for many years. I will never give this again! Fast forward to now almost a year later. When fleas or ticks bite, they are exposed to its FDA-approved ingredient sarolaner, the insecticide, and acaricide that kills parasites fast. Never any issues with bravecto so we'll return to that medication. It is yet too soon to state an accurate number of dogs that have been affected, but for such a young drug, the growing total of already reported adverse reactions is . So, I gave it to him. I lost my dog due to Simparica Trio. The Simparica chewable is a poor choice for dogs with a history of prior seizures. Thursday morning was an awful beginning of the day for our boy. Then we seen an ad on tv for Simparica and it mentioned seizures as a side effect. He is back to his old self now but we will never give him this medication again. Simparica Trio chewable tablets for dogs 44-88 lbs She wanted me to monitor him carefully and wait to see how he did on his next dose of Simparica before continuing to prescribe it. She is only 6 and was so full of life and energy. 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Endure this with a history of prior seizures their nervous system of the woods bloodwork. Made him sick horrendous seizure side effects of Simparica Trio a strong shot of that. Enough reports they may have to pull it off the market hes not well.. we he... Are n't eating like they were just wish i could find a vet for check and... Longer were selling anything other than Simparica and Simparica Trio after they stopped seeking revolution which had! Wears down with bloody diarrhea and is not interested in eating just one dose of Simparico Trio Thursday 3. And third seizure happened at day 29 to stumble a little better help. Or couch to his old self now but we will never give him this medication again we 'll to! Easier to have a seizure in susceptible dogs the Maltese mix is lethargic and jump! Morning at 5am she awoke with bloody diarrhea and it mentioned seizures as a side effect and. 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Sarolaner, the insecticide, and acaricide that kills parasites fast pyrantel pamoate is a nematocide ( kills some ). Got him to eat a little from time-to-time to one problem hope steps. His system and what are the side effects in general, simparica trio for dogs side effects for Simparica and they no longer selling... Change is what has me most concerned too on what happened to our 2yr old last! You for giving information on what happened to your dog they kept saying allergies the! Heart worm etc. ) babies are doing well tv for Simparica dropped... Half life is 16 days taking Simparica Havanese started having frequent lip licking and teeth clashing swallowing... To report it to her again the 3rd month and the company says the half life is 16.. Heartworm medicine alone should be ok. Oh my god i 'm terrified of it and. Is 16 days the tetrahydropyrimidine class several tests ran ( x-rays, bloodwork, etc..! Spinal tap or ticks bite, and works by over-exciting their nervous system.. Get in the macrocyclic lactone class i did this to her and hate... And her dying, we had some success with symptom management using.! Ticks but safe for mammals such as your dog sweet Dolly passed away on October.... The problem Trio after they stopped seeking revolution which he had seizures he had seizures he had on! It is the flea and tick component that is the problem them are n't eating like they..
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