lutein eye drops benefits

Johnson E.J., Vishwanathan R., Johnson M.A., Hausman D.B., Davey A., Scott T.M., Green R.C., Miller L.S., Gearing M., Woodard J., et al. RCT, healthy participants (120); treatment group (60) vs. placebo (60). Read our, Study Highlights the Safest Supplements to Slow Age-Related Macular Degeneration, All-Natural Strategies to Prevent Cataracts, How Age-Related Macular Degeneration Is Treated, 15 Anti-Inflammatory Foods You Should Be Eating, Vitamin C: Uses, Side Effects, Dosage, and Interactions, Why Your Body Needs Folate and How to Get Enough. Effects of supplemental beta-carotene, cigarette smoking, and alcohol consumption on serum carotenoids in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. The structure of L is similar to that of other carotenoids, with a skeleton made up of 40 carbon atoms, organized into eight isoprene units [45], as shown in Figure 1. Bakker M.F., Peeters P.H., Klaasen V.M., Bueno-de-Mesquita H.B., Jansen E.H., Ros M.M., Travier N., Olsen A., Tjnneland A., Overvad K., et al. As reported above, mammalians are not able to synthesize carotenoids which therefore need to be introduced with food [11]. Effects of a lutein and zeaxanthin intervention on cognitive function: A randomized, double-masked, placebo-controlled trial of younger healthy adults. Kijlstra A., Tian Y., Kelly E.R., Berendschot T.T. In older women, Johnson et al. Zhou Y., Wang T., Meng Q., Zhai S. Association of carotenoids with risk of gastric cancer: A meta-analysis. Lutein is found mainly in the inner plexiform layer and in Henles fiber layer [47] but it can also be found in Mller cells [48]. Atherosclerosis and cardiovascular (CV) health partly depend on the activation of inflammatory cytokines [149]; therefore, nutrients and drugs that favorably influence the cytokine cascade might effectively prevent CV damage. A European multicentre, placebo-controlled supplementation study with alpha-tocopherol, carotene-rich palm oil, lutein or lycopene: Analysis of serum responses. Furthermore, in rats L countered the oxidative stress induced by hyper-homocysteinemia [152], a minor CV risk factor [153,154] and prevented cardiac and renal injury induced by streptozotocin in association with reduced oxidative stress markers [155]. Cathy Wong is a nutritionist and wellness expert. In research, lutein supplements have been used safely in doses up to 15 mg daily for up to two years. Age-Related Eye Disease Study 2 (AREDS2) Research Group. Wang X., Jiang C., Zhang Y., Gong Y., Chen X., Zhang M. Role of lutein supplementation in the management of age-related macular degeneration: Meta-analysis of randomized controlled trials. Grudzinski W., Piet M., Luchowski R., Reszczynska E., Welc R., Paduch R., Gruszecki W.I. Leermakers E.T., Darweesh S.K., Baena C.P., Moreira E.M., Melo van Lent D., Tielemans M.J., Muka T., Vitezova A., Chowdhury R., Bramer W.M., et al. Lutein is a xanthophyll, i.e., an oxygenated carotenoid that all mammalians, humans included, derive from their diet because they are unable to synthesize carotenoids [11]. Furthermore, in the Combination of Lutein Effects in the Aging Retina (CLEAR) study, the MPOD of 72 patients with AMD significantly increased after one year of L supplementation (10 mg/d) [16]. suggested that L plasma levels were inversely associated with circulating levels of oxidized LDL [161], whereas low circulating levels of L were associated with an increased risk of developing atrial fibrillation [162]. Seddon J.M., Ajani U.A., Sperduto R.D., Hiller R., Blair N., Burton T.C., Farber M.D., Gragoudas E.S., Haller J., Miller D.T., et al. Interestingly, an RCT reported that L protected the skin against the damage induced by solar radiation [191]; Palombo et al. However, the absence of similar data throughout recent decades makes also this association unlikely. Intervention trial, participants with AMD (79); 2 groups: G1 (40); G2 (39). Dawczynski J., Jentsch S., Schweitzer D., Hammer M., Lang G.E., Strobel J. Lutein: More than just a filter for blue light. Jacques P.F., Taylor A., Moeller S., Hankinson S.E., Rogers G., Tung W., Ludovico J., Willett W.C., Chylack L.T., Jr. Serum carotenoids and tocopherols and incidence of age-related nuclear cataract. Aleman T.S., Duncan J.L., Bieber M.L., de Castro E., Marks D.A., Gardner L.M., Steinberg J.D., Cideciyan A.V., Maguire M.G., Jacobson S.G. Macular pigment and lutein supplementation in retinitis pigmentosa and Usher syndrome. Intervention trial, healthy participants (37); 3 groups: G1 (12); G2 (12); G3 (13). A one year study of the macular pigment: The effect of 140 days of a lutein supplement. Rosenthal J.M., Kim J., de Monasterio F., Thompson D.J., Bone R.A., Landrum J.T., de Moura F.F., Khachik F., Chen H., Schleicher R.L., Ferris F.L., III, Chew E.Y. Many studies in humans have also provided evidence for a beneficial role of L supplementation, lowering the blood concentrations of inflammatory cytokines, while favoring the secretion of anti-inflammatory cytokines [39]. In a case-control study including 421 individuals with neovascular AMD and 615 controls, it was found that the odds ratio (OR) of developing AMD was 0.3 when the highest quintile of L serum concentrations was compared with the lowest quintile, hypothesizing a negative relationship between L levels and AMD risk [103]. Antioxidant micronutrients and the risk of renal cell carcinoma in the Womens Health Initiative cohort. Lutein and zeaxanthin content of some fresh foods (mean serving) a. a [88]; L, lutein; Z, zeaxanthin; c cup; e 1 large egg; l 5 leaves; t 1 teaspoon; L. Age-related macular degeneration (AMD) is the main cause of vision impairment and blindness in developed countries [89,90]. Thus, not only high L intake with a diet rich in fruit and vegetables, but also its supplementation might be encouraged, particularly in the elderly and in individuals at high risk of different clinical conditions. RCT, participants with at least bilateral early AMD (433); intervention group (216) vs. placebo (217), Intervention group: formulation containing L 12 mg. No significant improvement in CS. The possibility to effectively treat this disabling disease with a safe nutritional intervention is a key issue and needs to be clarified. Significant improvement in VA and CS after 2 years. However, a meta-analysis reported a significant negative association between L serum levels and risk of nuclear cataract [121] and another meta-analysis of 6 cohort studies including more than 40,000 participants concluded that daily L intake was negatively associated with the risk of developing nuclear cataract in a dose-linear response [122]. National Library of Medicine [207] reported that subjects receiving L supplementation of 15 mg/d for 20 weeks developed skin yellowing [carotenodermia], an innocuous but unpleasant side effect. Positive correlation between MPOD increase, VA and CS. Relationship between serum and brain carotenoids, -tocopherol, and retinol concentrations and cognitive performance in the oldest old from the Georgia Centenarian Study. Bone health is of great importance, especially in the elderly as decreased bone mineral density may lead to osteoporosis and fractures [187]. Additionally, health experts note that taking up to 20 mg of lutein both from the diet and supplements seems to be safe.. Long-term nutrient intake and 5-year change in nuclear lens opacities. According to three studies, L supplementation with 20 mg/d was not more effective than the dose of 10 mg/d in improving visual performance [34,35,36]. Carotenoids and colon cancer. Sequential patterns of inhibin subunit gene expression following hypoxic-ischemic injury in the rat brain. Studies performed both in animals [198,199] and in-vitro [199] clearly demonstrated that the use of L is safe as no mutagenic or teratogenic effect was observed. Parahippocampal cortex mediates the relationship between lutein and crystallized intelligence in healthy, older adults. Same efficacy in all treatment groups. Melo van Lent D., Leermakers E.T.M., Darweesh S.K.L., Moreira E.M., Tielemans M.J., Muka T., Vitezova A., Chowdhury R., Bramer W.M., Brusselle G.G., et al. S.B. Plasma beta-carotene response in humans after meals supplemented with dietary pectin. Lutein. Fujimura S., Ueda K., Nomura Y., Yanagi Y. ); ti.obinu@inisehcram.oiluig (G.M. RCT, healthy participants (121); intervention group (61) vs. placebo (60), Intervention group: formulation containing L 12 mg + Z 1 mg. After 1 year, significant effect on MPOD but no improvement in VA, CS, glare disability, recovery from photostress. Lai M., Sirimanne E., Williams C.E., Gluckman P.D. To date, most of the studies on lutein's health benefits have focused on dietary intake of lutein. supervised, proofread, revised and approved the final version. A diet rich in fiber has been reported to reduce carotenoid serum levels [62,63], also affecting L absorption, whereas the presence of other carotenoids in diet might interfere with L assimilation, probably via a competitive mechanism [64]. Zheng et al. Dietary carotenoids, vitamins C and E, and risk of cataract in women: A prospective study. Lutein and zeaxanthin influence brain function in older adults: A randomized controlled trial. The study's findings also suggest that lutein supplements may help treat vision problems brought on by long-term exposure to light from computer screens., A 2018 review of research concluded that there are many studies supporting lutein beneficial effects on eye health. Memorial Sloan Kettering Cancer Center. 2022 Dotdash Media, Inc. All rights reserved. Zamroziewicz M.K., Paul E.J., Zwilling C.E., Johnson E.J., Kuchan M.J., Cohen N.J., Barbey A.K. Federal government websites often end in .gov or .mil. Huang J., Lu M.S., Fang Y.J., Xu M., Huang W.Q., Pan Z.Z., Chen Y.M., Zhang C.X. Palombo P., Fabrizi G., Ruocco V., Ruocco E., Fluhr J., Roberts R., Morganti P. Beneficial long-term effects of combined oral/topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: A double-blind, placebo-controlled study. HHS Vulnerability Disclosure, Help Two recent meta-analyses including L randomized clinical trials (RCTs) demonstrated beneficial effects of L on MPOD [32] and VA [33] development. In the same cohort, the dietary L intake was associated with the risk of AMD, and again an OR of 0.43 was observed comparing the highest vs. the lowest quintile of dietary L intake [10]. Therefore, in the presence of an insufficient average intake of L of approximately 1.4 mg/d, supplementation of 10 mg/d, as in the AREDS2, might be the most appropriate dosage for chronic L supplementation. The original studies that first investigated a possible protective role of L against AMD date back to the early 1990s. Subczynski et al. official website and that any information you provide is encrypted In general, sustained lutein consumption, either through diet or supplementation, may contribute to reducing the burden of several chronic diseases. Nataraj J., Manivasagam T., Thenmozhi A.J., Essa M.M. By functional magnetic resonance imaging, it has been observed that L may improve cerebral perfusion [141] or neural efficiency in older adults [142] and two studies have demonstrated a relationship between MPOD and some aspects of cognitive function as prospective memory [143] or verbal fluency and processing speed [144]. Junghans A., Sies H., Stahl W. Macular pigments lutein and zeaxanthin as blue light filters studied in liposomes. Korobelnik J.F., Rougier M.B., Delyfer M.N., Bron A., Merle B.M.J., Savel H., Chne G., Delcourt C., Creuzot-Garcher C. Effect of Dietary Supplementation with Lutein, Zeaxanthin, and -3 on Macular Pigment: A Randomized Clinical Trial. Relationship of lutein and zeaxanthin levels to neurocognitive functioning: An fMRI study of older adults. Kim J.E., Leite J.O., DeOgburn R., Smyth J.A., Clark R.M., Fernandez M.L. Homocysteine Studies Collaboration Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis. Kuchan M., Wang F., Geng Y., Feng B., Lai C. Advances and Controversies in Clinical Nutrition. Carotenoids are nutrients widely distributed in foods, especially in fruit and vegetables [4], and appear to have antioxidant properties [5,6]. However, conflicting data had been reported concerning L efficacy [22,23,24,25,26,27,28,29,30], and in 2006, it was claimed that no compelling evidence had been provided concerning the supposed beneficial effect of L on human health [31]. Gale C.R., Hall N.F., Phillips D.I., Martyn C.N. Changes following supplementation with lutein and zeaxanthin in retinal function in eyes with early age-related macular degeneration: A randomised, double-blind, placebo-controlled trial. Effects of lutein on the growth and migration of bovine lens epithelial cells in vitro. More recently, a number of studies have suggested that L may indeed have favorable effects via anti-inflammatory activity [39], improving cognitive functions [40], and decreasing the risk of cancer [41], cardiovascular diseases [39] and other systemic conditions [42,43,44]. Effects of lutein supplement on serum inflammatory cytokines, ApoE and lipid profiles in early atherosclerosis population.

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