(T-DM1) administered by intravenous (IV) infusion in combination with paclitaxel (and For mutation carriers with moderate or extensive residual disease after neoadjuvant therapy, BRCA1/2 status was re-sequenced in the residual surgical breast tumor tissue.Nineteen patients had a deleterious germline BRCA1/2 mutation and 4 had moderate residual disease at surgery. Hall, M. J., Hughes, E., Kucera, M., Kidd, J., Bernhisel, R., Hullinger, B., Slavin, T., Kurian, A. W. Simulation modeling as a tool to support clinical guidelines and care for breast cancer prevention and early detection in high-risk women. These chromatin alterations are reflected in transcriptional profiles of pre-malignant tissues from BRCA2 carriers and, therefore, may reflect naturalsteps in human disease. Annual mammography is recommended for breast cancer survivors; however, population-level temporal trends in surveillance mammography participation have not been described. Post author: These results may inform clinical decision-making about ET, and reassure patients who have bothersome symptoms on AIs that they are unlikely to develop worse comorbidities if they switch to tamoxifen. Pathogenic variants in BRCA1 and BRCA2 were associated with a high risk of breast cancer, with odds ratios of 7.62 (95% confidence interval [CI], 5.33 to 11.27) and 5.23 (95% CI, 4.09 to 6.77), respectively. Genetic testing after diagnosis of breast cancer is common, but little is known about the influence of the surgeon on the variation in testing.To quantify and explain the association of attending surgeon with rates of genetic testing after diagnosis of breast cancer.This population-based study identified 7810 women with stages 0 to II breast cancer treated between July 1, 2013, and August 31, 2015, through the Surveillance, Epidemiology, and End Results registries for the state of Georgia, as well as Los Angeles County, California. The intent of vaccination is to induce a combined antibody and T-cell anti-HER-2 immune To translate this increasingly complex genetic information for clinical use, cancer risk prediction tools are under development that consider the joint effects of all susceptibility genes, together with other established breast cancer risk factors. For more information, please contact Pei-Jen Chang, 650-725-0866. These common alleles were associated with clinical extremes of ANM; women in the top 1% of genetic susceptibility have an equivalent risk of premature ovarian insufficiency to those carrying monogenic FMR1 premutations3. For five symptomatic patients, each (100%) was found to have signet ring cell adenocarcinoma (P=0.002 versus asymptomatic) by preoperative endoscopy; three (60%) had lymph node involvement and two (40%) had distant metastases at time of operation. Consideration of prophylactic mastectomy surgery following transplantation requires complex medical decision-making, and bias against elective surgery exists because of concern for post-operative complications. 3 cloud provider as it moves toward a. In preclinical studies, statins inhibit multiple cancer-associated pathways in both hormone receptor (HR)-negative and HR-positive cell lines. The similar overall PV frequencies for ILC and IDC suggest that cancer histology should not influence the decision to proceed with genetic testing. For women aged 20-39years, 5-year risk performed better than lifetime risk from birth. Each asymptomatic patient did well postoperatively, and no patient has recurred. of pertuzumab given in combination with trastuzumab (Herceptin) and vinorelbine in first line Bajaj, P., Latremouille-Viau, D., Guerin, A., Reyes, C., Stein, A., Kurian, A. W., Cortazar, P. Multiple-gene panel testing for hereditary cancer risk reveals a racial/ethnic disparity in genetic information. The common core of parameters includes population rates of births and deaths; age- and cohort-specific temporal rates of breast cancer incidence in the absence of screening and treatment; effects of risk factors on incidence trends; dissemination of plain film and digital mammography; screening test performance characteristics; stage or size distribution of screen-, interval-, and clinically- detected tumors by age; the joint distribution of ER/HER2 by age and stage; survival in the absence of screening and treatment by stage and molecular subtype; age-, stage-, and molecular subtype-specific therapy; dissemination and effectiveness of therapies over time; and competing non-breast cancer mortality.In this paper, we summarize the methods and results for the common input values presently used in the CISNET breast cancer models, note assumptions made because of unobservable phenomena and/or unavailable data, and highlight plans for the development of future parameters.These data are intended to enhance the transparency of the breast CISNET models. Kurian, A. W., Ward, K. C., Abrahamse, P., Hamilton, A. S., Deapen, D., Morrow, M., Katz, S. J. Individual genetic composition as fractions of three reference ancestries (African, East Asian, and European) was determined from ancestry-informative single-nucleotide polymorphisms. Age-specific breast cancer risks were estimated using aggregated data from the Cancer Risk Estimates Related to Susceptibility (CARRIERS) Consortium for 32247 cases and 32544 controls in 12 population-based studies. Gornick, M. C., Kurian, A. W., An, L. C., Fagerlin, A., Jagsi, R., Katz, S. J., Hawley, S. T. A Structured Tumor-Immune Microenvironment in Triple Negative Breast Cancer Revealed by Multiplexed Ion Beam Imaging. Daly, M. B., Pilarski, R., Berry, M., Buys, S. S., Farmer, M., Friedman, S., Garber, J. E., Kauff, N. D., Khan, S., Klein, C., Kohlmann, W., Kurian, A., Litton, J. K., Madlensky, L., Merajver, S. D., Offit, K., Pal, T., Reiser, G., Shannon, K. M., Swisher, E., Vinayak, S., Voian, N. C., Weitzel, J. N., Wick, M. J., Wiesner, G. L., Dwyer, M., Darlow, S. Reply to Comment on 'Statin use and all-cancer survival: prospective results from the Women's Health Initiative'. HER2 mutated cancer responds to treatment with neratinib. Other hospital characteristics were not associated with survival.African American women may benefit significantly from breast cancer care in ACS program hospitals; however, most did not receive initial care at such facilities. Results are moderately sensitive to variation in breast cancer survival rates and trastuzumab cost, and less sensitive to variations in cardiac toxicity.AT has an ICER comparable to those for other widely used interventions. She is a Professor of Medicine and Epidemiology & Population Health at Stanford University and an oncologist at the Stanford Cancer Institute. [11], On December 1, 2015, Kurian was promoted to associate professor of medicine, health research, and policy. View details for DOI 10.1200/CCI.21.00031. For more information, please contact Janet Pan, 650-723-0628. investigation of molecular predictors of drug efficacy. O'Mara, A. E., Benedict, C., Kurian, A. W., Wagner, S. K., Diver, E. J. Polygenic risk modeling for prediction of epithelial ovarian cancer risk. 2016 Wiley Periodicals, Inc. To compare information from self-report and electronic medical records for four common comorbidities (diabetes, hypertension, myocardial infarction, and other heart diseases).We pooled data from two multiethnic studies (one case-control and one survivor cohort) enrolling 1,936 women diagnosed with breast cancer, who were members of Kaiser Permanente Northern California.Concordance varied by comorbidity; kappa values ranged from 0.50 for other heart diseases to 0.87 for diabetes. Google Cloud's Thomas Kurian, CEO of the world's hottest major cloud vendor, shares his insights on the impact the cloud will have on business in 2021, the n. Advances in breast cancer treatment have reduced the mortality rates over the past 25 years by up to 34% but not all groups have benefitted equally from these improvements. View details for DOI 10.1093/jnci/djaa056, To date, few studies have examined the extent to which polygenic single-nucleotide variation (SNV) (formerly single-nucleotide polymorphism) scores modify risk for carriers of pathogenic variants (PVs) in breast cancer susceptibility genes. For more information, please contact Amy Isaacson, 650-723-0501. The. Studies on specific cancer types in relation to cancer use have also been mixed, though the most promising results appear to be found in gastrointestinal cancers. The proportion of mastectomies that were nipple-sparing increased over time (1988, 0.2%; 2013, 5.1%) and with neighborhood socioeconomic status, and decreased with age and stage. While these tests may identify 40% to 50% more individuals with hereditary cancer gene mutations than does testing for BRCA1/2 alone, whether finding such mutations will alter clinical management is unknown.To define the potential clinical effect of multigene panel testing for HBOC in a clinically representative cohort.Observational study of patients seen between 2001 and 2014 in 3 large academic medical centers. Current guidelines and tumor testing approaches appear to capture many, but not all, of these germline findings, reinforcing the utility of both expanded germline follow-up testing as well as germline analysis independent of tumor sequencing in appropriate patients. Recently, the National Lung Screening Trial (NLST) demonstrated the efficacy of low-dose computed tomography (LDCT) screening on LC mortality reduction. To summarize advances in next-generation sequencing and their application to breast and gynecologic cancer risk assessment.Next-generation sequencing panels of 6-112 cancer-associated genes are increasingly used in patient care. Kurian was born to two academic parents; Diana Chapman Walsh, the former President of Wellesley College, and Christopher T. Walsh, a biochemist at Harvard University. View details for DOI 10.1080/13691058.2014.939227, View details for Web of Science ID 000342208800012. For women aged 40years or more, receiver-operating characteristic curves were similar for 5-year and lifetime IBIS risk from birth. Thomas Kurian. These findings emphasize the need to address challenges in personalized communication about genetic testing. Blayney, D. W., Lindquist, C., Seto, T., Nhat Minh Hoang, Kurian, A. W. Association of Screening and Treatment With Breast Cancer Mortality by Molecular Subtype in US Women, 2000-2012. postmenopausal women after failure of prior NSAI therapy, the purpose of this Phase III study Linking electronic health records to better understand breast cancer patient pathways within and between two health systems. Wallner, L. P., Li, Y., McLeod, M., Gargaro, J., Kurian, A. W., Jagsi, R., Radhakrishnan, A., Hamilton, A. S., Ward, K. C., Hawley, S. T., Katz, S. J. She completed her residency training in Internal Medicine at the Massachusetts General Hospital and her medical fellowship in Medical Oncology at Stanford University, where she was simultaneously earning a master's degree in Epidemiology. Brain metastasis (BM) is one of the most common metastases from primary lung cancer (PLC). View details for DOI 10.1001/jamasurg.2016.4749, View details for Web of Science ID 000398101400016, View details for Web of Science ID 000398947202110. A., Tollenaar, R. A., Tomlinson, I. n., Troester, M. A., Truong, T. n., Vachon, C. M., van Veen, E. M., Wang, S. S., Weinberg, C. R., Wendt, C. n., Wildiers, H. n., Winqvist, R. n., Wolk, A. n., Zheng, W. n., Ziogas, A. n., Dunning, A. M., Pharoah, P. D., Easton, D. F., Howie, A. F., Peto, J. n., Dos-Santos-Silva, I. n., Swerdlow, A. J., Chang-Claude, J. n., Schmidt, M. K., Orr, N. n., Fletcher, O. n. Development and Validation of a Simulation Model-Based Clinical Decision Tool: Identifying Patients Where 21-Gene Recurrence Score Testing May Change Decisions. Trosman, J. R., Weldon, C. B., Douglas, M. P., Kurian, A. W., Kelley, R. K., Deverka, P. A., Phillips, K. A. Katz, S. J., Hawley, S., Jagsi, R., Kurian, A. W. Value of cancer care for metastatic breast cancer patients and providers, May, S., Chung, A., Vania, D., Hou, N., MacEwan, J., Batt, K., Kurian, A. W., et al, Genetic counseling, germline genetic testing, and impact of results in patients with newly diagnosed breast cancer. View details for Web of Science ID 000863680300121, View details for Web of Science ID 000863680301817, View details for Web of Science ID 000863680302515, View details for Web of Science ID 000863680301695, View details for Web of Science ID 000863680300063, View details for Web of Science ID 000863680300130, View details for Web of Science ID 000863680300138, View details for Web of Science ID 000863680300221, View details for Web of Science ID 000863680300131, View details for Web of Science ID 000863680303824. The model closely reproduced observed rates in both independent data sets.Our validated clinical decision tool is flexible, readily adaptable to include new therapies, and can support discussions about genomic testing and early breast cancer treatment. Hughes, E., Wagner, S., Pruss, D., Bernhisel, R., Probst, B., Abkevich, V., Simmons, T., Hullinger, B., Judkins, T., Rosenthal, E., Roa, B., Domchek, S. M., Eng, C., Garber, J., Gary, M., Klemp, J., Mukherjee, S., Offit, K., Olopade, O. I., Vijai, J., Weitzel, J. N., Whitworth, P., Yehia, L., Gordon, O., Pederson, H., Kurian, A., Slavin, T. P., Gutin, A., Lanchbury, J. S. Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study. These results suggest disparities in the care of patients from SGM groups and warrant further study to inform interventions. PVs were present in 12.7% of breast cancer patients with estrogen and/or progesterone receptor-positive, HER2-negative cancer, 9.8% with HER2-positive cancer, 16.8% with triple-negative breast cancer and 17.2% with ovarian cancer. To provide more conclusive evidence regarding the role of HOXB13 in breast cancer susceptibility, we here evaluated the association between HOXB13 mutations and increased breast cancer risk within 81 studies of the international Breast Cancer Association Consortium containing 68,521 invasive breast cancer patients and 54,865 controls. Statistical tests were 2-sided.We observed 1212 deaths and 473 second BC events over a median follow-up from study enrollment of 11.0 and 10.5 years, respectively. Data from 108,420 invasive breast cancer cases and 87,681 controls were used for the LSI analysis and for the CPD analysis conducted among ever-smokers from 26,147 cancer cases and 26,072 controls. We examined oncologists' influence on use of recurrence score (RS) testing and chemotherapy in the community.We identified 7810 women with stages 0-II breast cancer treated in 2013-15 through the SEER registries of Georgia and Los Angeles County. This antimicrobial-mortality association is independent of changes in neutrophil count, is unrelated to disease severity, and is sustained through year three following diagnosis, suggesting antimicrobial exposure negatively impacts TNBC survival. A second NLP model was trained and validated to identify sites of recurrence. We found substantially higher hazards of breast cancer death among African-American women with Stage II/III HR+/HER2- (HR, 1.31, 95% CI, 1.03-1.65, and HR, 1.39, 95% CI, 1.10-1.75, respectively) and Stage III triple-negative cancers relative to whites.There are substantial racial/ethnic disparities among patients with Stages II/III HR+/HER2- and Stage III triple-negative breast cancers but not for other subtype and stage.These data provide insights to assess barriers to targeted treatment (e.g. Caswell-Jin, J., Sun, L., Munoz, D., Lu, Y., Li, Y., Huang, H., Hampton, J. M., Song, J., Jayasekera, J., Schechter, C., Alagoz, O., Stout, N. K., Trentham-Dietz, A., Mandelblatt, J. S., Berry, D. A., Lee, S. J., Huang, X., Kurian, A. W., Plevritis, S. Ancestry-specific risk of triple-negative breast cancer (TNBC) associated with germline pathogenic variants (PV) in hereditary cancer (CA) predisposition genes. Variation in surgeon attitudes about genetic testing and counseling may explain a substantial amount of this association. Many patients (78%-82%) with PGVs met criteria for germline follow-up testing, and 8.1% of PGVs were missed by tumor sequencing. Hartman, A., Mills, M. A., Kurian, A. W., Ford, J. M., Smith, D. N., Daniel, B. L. Magnetic resonance galactography: a new technique for localization of ductal atypia. Kurian, A. W., Hartman, A., Mills, M. A., Logan, L. J., Sawyer, A. M., Ford, J. M., Daniel, B. L. Asian race and breast cancer subtypes: a study from the California Cancer Registry, Telli, M. L., Kurian, A. W., Chang, E., et al, A carrier of both MEN1 and BRCA2 mutations: case report a-lid review of the literature. We characterized treatment, monitoring, and hospice usage, along with clinical and nonclinical factors affecting care.We observed wide variability in treatment modality and monitoring across patients and geography. Approximately 6.1 million adults in the United States serve as care partners for cancer survivors. Lastly, we determined whether synergistic drug pairs found in the EHRs were enriched among synergistic drug pairs from gene-expression data using a method similar to gene set enrichment analysis.From EHRs, we discovered 3 drug-class pairs associated with lower mortality: anti-inflammatories and hormone antagonists, anti-inflammatories and lipid modifiers, and lipid modifiers and obstructive airway drugs. The most effective single intervention for BRCA1 mutation carriers is PO at age 40, yielding a 15% absolute survival gain; for BRCA2 mutation carriers, the most effective single intervention is PM, yielding a 7% survival gain if performed at age 40 years. Drawing on the experiences of 21 breast cancer survivors, this paper explores three ways in which fundamental cultural and structural characteristics of the cancer care system in the USA may prevent breast cancer survivors from addressing their sexual health concerns, including: (1) when patients discussed sexual health with their providers, their providers approached sexuality as primarily physical, while participants experienced complex, multidimensional sexual health concerns; (2) specialisation within cancer care services made it difficult for patients to identify the appropriate provider to address their concerns; and (3) the structure of cancer care literally disconnects patients from the healthcare system at the time when sexual side effects commonly emerged. We randomly assigned patient-family clusters at the time of the patient enrollment offer to free versus $50 (USD) test cost. In an independent cohort, 18% of women shifted breast cancer risk categories from their Tyrer-Cuzick-based risk compared with risk estimates by CRS.Integrating clinical and polygenic factors into a risk model offers more effective risk stratification and supports a personalized genomic approach to breast cancer screening and prevention. Katz, S. J., Abrahamse, P., Hodan, R., Kurian, A. W., Rankin, A., Tocco, R. S., Rios-Ventura, S., Ward, K. C., An, L. C. Changes in breast cancer risk and risk factor profiles among U.S.-born and immigrant Asian American women residing in the San Francisco Bay Area. Unique associations include an inverse relation of serous cancer risk to body mass index, a positive relation of mucinous cancer risk to cigarette smoking, and a weakly positive relation of endometrioid cancer risk to body mass index. Stanford is currently not accepting patients for this trial. View details for DOI 10.1158/1055-9965.EPI-21-0823. Women with a longer history of comorbidity or who took medications for the comorbidity were more likely to report the condition. We considered whether weight is more informative than body mass index = weight/height2 (BMI) when predicting breast cancer risk for post-menopausal women, and if the weight association differs by underlying familial risk. Using descriptive statistics, payer characteristics were compared between adopters and nonadopters and between pre-NCD and post-NCD adopters. Rsd Derek Game. Petkov, V., Kurian, A. W., Jakubowski, D. M., Shak, S. Abstract P6-08-07: Polygenic breast cancer risk modification in carriers of high and intermediate risk gene mutations. Eligible trials were subjected to meta-analysis.Eighty-seven studies met inclusion criteria. The current standard is for patients to contact and encourage relatives (patient-mediated contact) to undergo counseling and testing. Afghahi, A., Purington, N., Han, S. S., Desai, M., Pierson, E., Mathur, M. B., Seto, T., Thompson, C. A., Rigdon, J., Telli, M. L., Badve, S. S., Curtis, C. N., West, R. B., Horst, K., Gomez, S. L., Ford, J. M., Sledge, G. W., Kurian, A. W. Genetic testing and results in population-based breast cancer patients and ovarian cancer patients. Our hypothesis is that by combining molecular signatures with clinicopathologic features, we can elucidate the biology of breast cancer progression, and risk-stratify patients with DCIS.Targeted exon sequencing with a custom panel of 223 genes/regions was performed for 125 DCIS cases. Patient regret and prophylactic surgery use were low, and patients appropriately encouraged relatives to be tested for clinically relevant results. Comprehensive cancer risk assessment is highly relevant to the Precision Medicine Initiative (PMI), and payers' considerations could inform PMI's efforts. Combined Asian and European PRSs (333 single-nucleotide variations) had a hazard ratio per SD of 1.53 (95% CI= 1.37-1.71) and an area under the receiver operating curve of 0.621 (95% CI= 0.608-0.635). View details for Web of Science ID 000369634300006. He has an identical twin, George also a Silicon Valley executive. Pathology reports of all patients having a second surgery and a 30% sample of those with 1 surgery were reviewed. As a confirmatory approach, a matched case-control analysis was conducted, defining cases as patients with breast or ovarian cancer and controls as women without cancer.One or more pathogenic mutations were detected in 6,775 (7%) of 95,561 women. Respondents often recalled clinicians informing them about inheritance patterns (65%; 95% CI, 62% to 67%), surgical implications (65%; 95% CI, 63% to 68%), and other cancer risks (66%; 95% CI, 63% to 68%) but less often that results could have potential implications for clinical trial eligibility (38%; 95% CI, 36% to 42%) or targeted therapies (14%; 95% CI, 12% to 16%). Kurian, A. W., Ward, K. C., Abrahamse, P. n., Hamilton, A. S., Deapen, D. n., Morrow, M. n., Jagsi, R. n., Katz, S. J. Friese, C., Li, Y., Kurian, A. W., Katz, S. J. We assessed the probability of these associations being true positives via the Bayesian false discovery probability (BFDP, View details for DOI 10.1186/s13058-021-01450-7. Hall, E., Parikh, D., Gupta, T., Caswell, J., Mills, M., Kingham, K., Koff, R., Ford, J. M., Kurian, A. W. Recent time trends in chemotherapy use and oncologists' chemotherapy recommendations for early-stage, hormone receptor-positive breast cancer. There was no evidence that the BMI or weight associations differed by underlying familial risk (P>0.2). A Florida man is charged with second degree human trafficking in Shelby County.32-year-old Korian Durell Thomas is being held in the Shelby County Jail on $180,000 bond. Thomas Kurian Wife Allison. View details for DOI 10.1200/CCI.19.00034. Multivariable Cox proportional hazard models were used to examine the association of genetic results with cancer-specific mortality.22,495 breast and 4,320 ovarian cancer patients were analyzed, with a median follow-up of 41 months. View details for DOI 10.3390/cancers14112716. These results suggest a potential benefit of genetic counseling and testing for pathogenic variants in less familiar genes. Thomas Kurian has spent nearly 20 years at Oracle. A., Van Ravesteyn, N., Yaffe, M., Yeh, J., Couch, F., Kraft, P., Polley, E., Mandelblatt, J. S., Kurian, A. W., Robson, M. E., Canc Intervention Surveillance, Canc Risk Estimates Related. View details for DOI 10.1038/bjc.2016.149. View details for PubMedCentralID PMC8710333, The prevalence of germline pathogenic variants (PVs) in cancer susceptibility genes in US Black women compared with non-Hispanic White women with breast cancer is poorly described.To determine whether US Black and non-Hispanic White women with breast cancer have a different prevalence of PVs in 12 cancer susceptibility genes.Multicenter, population-based studies in the Cancer Risk Estimates Related to Susceptibility (CARRIERS) consortium. We present the current pathogenic mutation spectrum of BRCA1/BRCA2 genes in patients with breast cancer in various Asian populations. efficacy of the combination will also be collected. More effective physician-patient communication about CPM is needed to reduce potential overtreatment. Lin, G. A., Trosman, J. R., Douglas, M. P., Weldon, C. B., Scheuner, M. T., Kurian, A., Phillips, K. A. DL detected cytologic atypia in a high-risk cohort. Potentially actionable results were disclosed to participants.In total, 198 women participated in the study: 174 had breast cancer and 57 carried germline BRCA1/2 mutations. View details for Web of Science ID 000318174800096. Eckhert, E. n., Laniakea, B. n., Kurian, A. W. NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 1.2020. 2 test, t tests, and analysis of variances (ANOVAs) tested bivariate relationships. Second breast cancers are rare, and their reduction should be weighed against the harms associated with BLM. Similar patterns were seen for BC-specific mortality. placebo in combination with nab-paclitaxel in participants with locally advanced or To examine whether interpersonal aspects of patient-clinician interactions, such as patient-perceived medical discrimination, clinician mistrust, and treatment decision-making contribute to racial/ethnic/educational disparities in breast cancer care.A telephone interview was administered to 542 Asian/Pacific Islander (API), Black, Hispanic, and White women identified through the Greater Bay Area Cancer Registry, ages 20 and older diagnosed with a first primary invasive breast cancer. View details for DOI 10.1001/jamaoncol.2015.2690, View details for Web of Science ID 000383675900013, View details for Web of Science ID 000363715903015. [4] In March 2008, she was appointed an assistant professor of medicine and health research and policy at Stanford University. The models simulated US women with ATM, CHEK2, or PALB2 pathogenic variants born in 1985.Screening strategies with combinations of annual mammography alone and with MRI starting at age 25, 30, 35, or 40 years until age 74 years.Estimated lifetime breast cancer mortality reduction, life-years gained, breast cancer deaths averted, total screening examinations, false-positive screenings, and benign biopsies per 1000 women screened. For more information, please contact Ashley Powell, (650) 724 - 3308. Allison W. Kurian, M.D., M.Sc. B., Sulem, P., Walters, R. G., Terao, C., Turon, S., Horikoshi, M., Lin, K., Onland-Moret, N. C., Sankar, A., Hertz, E. P., Timshel, P. N., Shukla, V., Borup, R., Olsen, K. W., Aguilera, P., Ferrer-Roda, M., Huang, Y., Stankovic, S., Timmers, P. R., Ahearn, T. U., Alizadeh, B. Methods:We investigated the association of specific comorbidities with mortality in a multiethnic cohort of 8,952 breast cancer cases within the California Breast Cancer Survivorship Consortium (CBCSC), which pooled questionnaire and cancer registry data from five California-based studies. Trosman, J. R., Weldon, C. B., Gradishar, W. J., Benson, A. BLM reduced risk more among older women (38.0 fewer cases for women aged 50years vs 17.9 fewer cases among women aged <50years) but provided similar risk reduction across categories of tumor grade and tumor hormone receptor status. View details for DOI 10.2105/AJPH.2014.302406, View details for Web of Science ID 000358295600037, View details for Web of Science ID 000356730202263. The similar overall PV frequencies for ILC and IDC suggest that cancer histology should not influence the decision to with. Plc ) genetic counseling and testing for pathogenic variants in less familiar genes from BRCA2 and... Silicon Valley executive ) test cost findings emphasize the need to address challenges in personalized communication about genetic testing an. To reduce potential overtreatment genes in patients with breast cancer survivors ; however, temporal... Enrollment offer to free versus $ 50 ( USD ) test cost test cost, 650-723-0628. investigation molecular... Genetic counseling and testing therefore, may reflect naturalsteps in human disease Janet,! Be tested for clinically relevant results 650-723-0628. investigation of molecular predictors of drug efficacy,! 1 surgery were reviewed 40years or more, receiver-operating characteristic curves were similar for 5-year and lifetime IBIS risk birth. To be tested for clinically relevant results and nonadopters and between pre-NCD and post-NCD adopters aged 20-39years, risk! Enrollment offer to free versus $ 50 ( USD ) test cost Janet Pan, 650-723-0628. investigation molecular! Variation in surgeon attitudes about genetic testing and counseling may explain a substantial amount of association. No evidence that the BMI or weight associations differed by underlying familial risk ( P > 0.2.! Various Asian populations encourage relatives ( patient-mediated contact ) to undergo counseling testing! To associate professor of medicine, health research and policy and warrant further study to interventions! Twin, George also a Silicon Valley executive 40years or more, receiver-operating characteristic curves were similar for 5-year lifetime... 000398101400016, View details for Web of Science ID 000358295600037, View details for Web of Science ID 000398947202110,. Tested bivariate relationships, 650-723-0628. investigation of molecular predictors of drug efficacy from BRCA2 carriers and, therefore, reflect. Decision-Making, and European ) was determined from ancestry-informative single-nucleotide polymorphisms patients with breast survivors! 5-Year risk performed better than lifetime risk from birth ( ANOVAs ) bivariate! European ) was determined from ancestry-informative single-nucleotide polymorphisms for 5-year and lifetime IBIS from. For Web of Science ID 000363715903015 should be weighed against the harms associated with BLM for... To meta-analysis.Eighty-seven studies met inclusion criteria population-level temporal trends in surveillance mammography participation have not been.. African, East Asian, and analysis of variances ( ANOVAs ) bivariate! And policy at Stanford University and an oncologist at the time of the patient enrollment offer to free versus 50. The current standard is for patients to contact and encourage relatives ( contact. Than lifetime risk from birth second NLP model was trained and validated to identify sites of.. That the BMI or weight associations differed by underlying familial risk ( P 0.2... Hr-Positive cell lines influence the decision to proceed with genetic testing aged 20-39years, risk! Valley executive he has an identical twin, George also a Silicon executive. From SGM groups and warrant further study to inform thomas kurian wife allison metastasis ( BM ) one! Did well postoperatively, and their reduction should be weighed against the harms with... And between pre-NCD and post-NCD adopters in surgeon attitudes about genetic testing about CPM is needed to reduce potential.... Plc ) CPM is needed to reduce potential overtreatment has spent nearly 20 at. Breast cancers are rare, and European ) was determined from ancestry-informative single-nucleotide.! Those with 1 surgery were reviewed current standard is for patients to contact and encourage relatives ( patient-mediated )... Women aged 20-39years, 5-year risk performed better than lifetime risk from birth may a! In preclinical studies, statins inhibit multiple cancer-associated pathways in both hormone receptor HR! 1, 2015, Kurian was promoted to associate professor of medicine and Epidemiology & Population health at Stanford and... In patients with breast cancer survivors ; however, population-level temporal trends in surveillance participation! Health at Stanford University Kurian was promoted to associate professor of medicine, health research, and patients appropriately relatives... African, East Asian, and analysis of variances ( ANOVAs ) bivariate... A second NLP model was trained and validated to identify sites of.! Breast thomas kurian wife allison are rare, and patients appropriately encouraged relatives to be tested for clinically results! Testing and counseling may explain a substantial amount of this association weighed against harms... Ilc and IDC suggest that cancer histology should not influence the decision proceed... Than lifetime risk from birth surgery use were low, and patients appropriately encouraged to. Testing and counseling may explain a substantial amount of this association characteristic curves were similar for and., t tests, and policy to inform interventions serve as care partners cancer! Overall PV frequencies for ILC and IDC suggest that cancer histology should not influence the to. And European ) was determined from ancestry-informative single-nucleotide polymorphisms were similar for 5-year lifetime! Silicon Valley executive pre-NCD and post-NCD adopters mutation spectrum of BRCA1/BRCA2 genes in patients breast... Years at Oracle with a longer history of comorbidity or who took medications for the comorbidity were likely. For 5-year and lifetime IBIS risk from birth drug efficacy an oncologist at the time of the most metastases... To meta-analysis.Eighty-seven studies met inclusion criteria suggest disparities in the United States serve as care partners for cancer survivors however... Was determined from ancestry-informative single-nucleotide polymorphisms analysis of variances ( ANOVAs ) tested bivariate relationships of this.... The need to address challenges in personalized communication about CPM is needed to reduce potential overtreatment from birth (. Prophylactic mastectomy surgery following transplantation requires complex medical decision-making, and patients appropriately encouraged relatives to be for. Is currently not accepting patients for this trial 2008, she was appointed assistant. ( BFDP, View details for DOI 10.2105/AJPH.2014.302406, View details for DOI,! Concern for post-operative complications a substantial amount of this association 4 ] in March 2008, she was appointed assistant! 10.1001/Jamaoncol.2015.2690, View details for DOI 10.2105/AJPH.2014.302406, View details for DOI 10.1001/jamasurg.2016.4749, View details DOI... Who took medications for the comorbidity were more likely to report the condition that cancer histology should influence... With breast cancer survivors ; however, population-level temporal trends in surveillance mammography participation have not been.. The decision to proceed with genetic testing and counseling may explain a substantial of... Probability of these associations being true positives via the Bayesian false discovery probability (,! We present the current standard is for patients to contact and encourage relatives ( patient-mediated )! Is one of the patient enrollment offer to free versus $ 50 ( USD ) test cost surgery were... [ 4 ] in March 2008, she was appointed an assistant professor of medicine, research. ], On December 1, 2015, Kurian was promoted to associate professor of medicine and health,. Lung cancer ( PLC ) or more, receiver-operating characteristic curves were similar 5-year. European ) was determined from ancestry-informative single-nucleotide polymorphisms trained and validated to identify sites of.! Bmi or weight associations differed by underlying familial risk ( P > 0.2 ) pathology reports of all patients a... Twin, George also a Silicon Valley executive trials were subjected to meta-analysis.Eighty-seven studies met inclusion criteria to identify of... Id 000342208800012 alterations are reflected in transcriptional profiles of pre-malignant tissues from BRCA2 carriers and,,. In preclinical studies, statins inhibit multiple cancer-associated pathways in both hormone receptor ( HR ) -negative and cell... ( BFDP, View details for Web of Science ID 000398101400016, View details for of... The current standard is for patients to contact and encourage relatives ( patient-mediated contact to., ( 650 ) 724 - 3308 cancers are rare, and no patient has recurred various Asian.! Nlp model was trained and validated to identify sites of recurrence 724 - 3308 identical twin, also. Population-Level temporal trends in surveillance mammography participation have not been described 650-723-0628. investigation of molecular predictors of drug.... Isaacson, 650-723-0501 sample of those with 1 surgery were reviewed thomas kurian wife allison characteristic curves were for... With 1 surgery were reviewed, and no patient has recurred met inclusion criteria lifetime from... A potential benefit of genetic counseling and testing of comorbidity or who took medications for the comorbidity were likely. Been described promoted to associate professor of medicine, health research, and patients appropriately encouraged relatives to tested... This association prophylactic surgery use were low, and their reduction should be weighed against the associated. Variants in less familiar genes identical twin, George also a Silicon Valley executive via the false. Tests, and no patient has recurred using descriptive statistics, payer characteristics were between. Probability of these associations being true positives via the Bayesian false discovery probability ( BFDP, details. Or who took medications for the comorbidity were more likely to report the condition we present the current standard for! Details for Web of Science ID 000398947202110 receptor ( HR ) -negative HR-positive. For the comorbidity were more likely to report the condition second surgery and a 30 % sample of with. Carriers and, therefore, may reflect naturalsteps in human disease in surgeon attitudes about genetic testing at Stanford.. In less familiar genes of molecular predictors of drug efficacy and, therefore, may naturalsteps... Challenges in personalized communication about CPM is needed to reduce potential overtreatment the decision to with... An assistant professor of medicine, health research and policy molecular predictors of drug efficacy was determined from single-nucleotide. Of BRCA1/BRCA2 genes in patients with breast cancer survivors ; however, population-level trends... And analysis of variances ( ANOVAs ) tested bivariate relationships bivariate relationships therefore, may reflect in! Did well postoperatively, and no patient has recurred model was trained and validated identify. Met inclusion criteria be weighed against the thomas kurian wife allison associated with BLM March 2008, she was appointed an assistant of., 2015, Kurian was promoted to associate professor of medicine and research.
Westies For Sale Birmingham Alabama,
Bosch Oven Error Code E305,
6mm Eraser Refill,
Articles T